03198nas a2200241 4500008004100000024000700041245018200048210006900230260001600299300001200315490000700327520231400334653003502648653002002683653003002703653003002733653004202763100002702805700002902832700003202861700002702893856003602920 2024 eng d a0400aPrevalence of Multidrug Resistant Organisms (MDROs) and Antimicrobial Sensitivity Pattern from clinical samples of the patients in Riyadh Province of the Kingdom of Saudi Arabia0 aPrevalence of Multidrug Resistant Organisms MDROs and Antimicrob cAugust 2024 a751-7560 v163 a

Background: Multidrug-Resistant organisms (MDRO) pose a global health threat due to overuse of antibiotics and genetic transfer of resistance. The Middle East, including Saudi Arabia, faces unique challenges in combating MDROs, necessitating tailored interventions. Objectives: This research aims to inform evidence-based treatment and infection control measures. By understanding local epidemiology, we can optimize antimicrobial prescribing and minimize resistance emergence. Comprehensive surveillance in diverse healthcare settings is crucial given the escalating antimicrobial resistance. Materials &Methods: This study utilized a retrospective design. Data was collected from diverse healthcare facilities, including hospitals, clinics, and laboratories, from March 2022 to February 2023. Sample size was determined using OpenEpi Software, with 1500 participants needed. Data collection involved reviewing microbiological records and laboratory reports, with deidentification of personal information. Ethical approval was obtained from Shaqra University, Saudi Arabia. Results: The study reported that 37.3% of the 1500 patients were classified as MDRO, with a higher prevalence among males (64.3%) compared to females (35.7%). MDRO prevalence varied across age groups, with the highest prevalence observed in the 70–79 age group (14.3%). Multiple invasive procedures (P = 0.002), length of stay (LOS) (P = 0.01) were independent risk factors for MDRO infection. Antimicrobial resistance patterns showed significant proportions of MDRO among Klebsiella spp., Acinetobacter spp., and Pseudomonas spp., Conclusion: The study emphasizes the urgent need for policy interventions to tackle the alarming prevalence of MDROs and combat antimicrobial resistance (AMR). Healthcare providers must prioritize antimicrobial stewardship and implement rigorous infection prevention measures to curb MDRO transmission. Future research should evaluate the impact of stewardship, monitor resistance trends, and explore novel treatment strategies. Collaboration among stakeholders is vital for addressing AMR comprehensively through knowledge sharing and capacity building initiatives.

10aantimicrobial resistance (AMR)10adrug resistance10adrug sensitivity patterns10aESBLs and Carbapenemases.10aMultidrug-Resistant organisms (MDROs)1 aAlsaab, Saad, Mohammed1 aAlotaibi, Salman, Khalid1 aBhaskaran, Prasanna, Mohana1 aDomnic, Inbaraj, Susai uhttps://phcogj.com/article/2335