02104nas a2200229   4500008004100000024000700041245014700048210006900195260001600264300001200280490000700292520134600299653001401645653001901659653002401678653003701702100002601739700002101765700002501786700002701811856003601838       2024                        eng d  a1400aMolecular Insights into Spirulina platensis Compounds Targeting TNFa and P21 in Delaying Cellular Senescence Mechanisms: An In Silico Approach0 aMolecular Insights into Spirulina platensis Compounds Targeting   cAugust 2024  a809-8150 v163 a<p class="rtejustify"><!-- x-tinymce/html -->Spirulina platensis with bioactive compounds such as Phycocyanin, β-carotene, Genistein and α-glucan, have been shown to have anti-inflammatory properties. Our present study investigation utilizes an in silico methodology to examine the molecular interactions between Spirulina platensis chemicals compound with TNFa and p21. Utilizing computational techniques molecular docking, our goal is to clarify the possible pathways by which Spirulina platensis chemicals could affect these important regulators and postpone cellular senescence. Our research may shed important light on the creation of Spirulina platensis-based therapies for ageing and age-related illnesses. Our results imply that Spirulina platensis may contribute to overall cellular health and the mitigation of cellular senescence. Phycocyanin has the most negative ΔG value is -15.0 kcal/mol. Genistein has the lowest Ki value, namely 7.299 μM. The ΔG and Ki values of Genistein were lower than Quercetin. The potential chemical interactions between substances generated from Spirulina platensis and senescence pathways, including those involving TNFa and p21, are highly intriguing for the development of innovative therapeutic approaches targeted at ameliorating cellular senescence dysfunction associated with aging.</p>
10ain silico10ap21 expression10aSpirulina platensis10aTNFa-induced cellular senescence1 aSusantiningsih, Tiwuk1 aFadilah, Fadilah1 aPrijanti, Ani, Retno1 aHardiany, Novi, Silvia  uhttps://phcogj.com/article/2344