02186nas a2200181 4500008004100000245012600041210006900167260001700236300001400253490000700267520158700274100002501861700002001886700001701906700002901923700001601952856003601968 2024 eng d00aThe Activity of Pegagan Embun Extract (Hydrocotyle sibthorpioides Lam.) in Capsule Form to SGPT and SGOT Levels in Humans0 aActivity of Pegagan Embun Extract Hydrocotyle sibthorpioides Lam cOctober 2024 a1015-10200 v163 a

Purpose: The study aimed to determine the activity of administering Hydrocotyle sibthorpioides Lam. extract in capsule dosage on SGPT and SGOT levels in humans. Methods: The participants involved 20 healthy volunteers aged 20-25 years who were divided into 2 groups with placebo as a comparison. The treatment groups were given capsules containing Hydrocotyle sibthorpioides Lam. extract at a dose of 67 mg. The other group administered a placebo containing lactose for 3 days. SGPT and SGOT levels were measured before and after consuming the test capsules. The examination of SGPT and SGOT levels was carried out using a 5010 v5+ photometer. Results: SGPT levels before the capsules were 28.79 U/L for the placebo and 28.59 U/L for the test preparation group. After administration of Hydrocotyle sibthorpioides Lam. extract capsules were 24.26 U/L and for placebo 32.86 U/L. At the same time, the measurement results of SGOT levels before being given the capsule were 17.37 U/L for the placebo and 17.71 U/L for the test preparation group. After administration of Hydrocotyle sibthorpioides Lam. extract capsules, it was 14.56 U/L and 18.52 U/L for placebo. The study results show that Hydrocotyle sibthorpioides Lam. extract significantly decreases SGPT and SGOT levels in humans (p<0.5). Conclusion: This result indicates that Hydrocotyle sibthorpioides Lam extract is relatively non-toxic and safe for public use as an immunostimulant herbal medicine.

1 aAfriwardi, Afriwardi1 aJulmiza, Adinny1 aUmar, Salman1 aAlianta, Aditya, Alqamal1 aAldi, Yufri uhttps://phcogj.com/article/2376