02314nas a2200205 4500008004100000245011300041210007000154260001800224300001400242490000700256520165100263653001801914653004901932653002301981653001502004100002802019700002002047700000502067856003602072 2024 eng d00aVDR and WNT/β-catenin Expression in Invasive Breast Carcinoma of No Special Type: Role and Prognostic Value0 aVDR and WNTβcatenin Expression in Invasive Breast Carcinoma of N cDecember 2024 a1349-13540 v163 a

Background: Breast cancer prognosis is closely related to tumor size (T stage). The Vitamin D receptor (VDR), found in about 80% of breast cancer cases, inhibits tumor growth, promotes differentiation, and enhances apoptosis. The growth of tumor cells is linked to β-Catenin, an essential element of the Wnt signaling pathway. Both β-catenin and VDR affect breast cancer aggressiveness. This study explored their correlation with the T stage of invasive breast carcinoma of no special type. Methods: This research employed a cross-sectional design, applied on paraffin-embedded specimens from patients with invasive breast cancer of no special type (NST) who underwent modified radical mastectomy (MRM) at Dr. Soetomo General Academic Hospital from January 2019 to June 2023. The samples were categorized into four groups based on the T stage. Immunohistochemical staining was performed using VDR and β-catenin antibodies. This study used analytic statistical methods to examine differences and correlations among VDR and β-catenin. Results: VDR expression and T stages were significantly different and negatively correlated. Expression of β-Catenin revealed significant differences and had positive correlations with T stages. VDR and β-catenin expressed no significant negative correlation with T stages. Conclusion: The study found significant differences and correlations between VDR and β-catenin expression with T stages in invasive breast carcinoma of NST. Both β-catenin and VDR play crucial roles in breast cancer cell proliferation.

10aBreast cancer10aInvasive breast carcinoma of no special type10aVitamin D Receptor10aβ-catenin1 aWanda, Dewi, Sartika Ar1 aSandhika, Willy1 a uhttps://phcogj.com/article/2431