02462nas a2200217 4500008004100000245020100041210006900242260001700311300001000328490000700338520168400345653005102029100002602080700002002106700000502126700001802131700001902149700001602168700002402184856003602208 2025 eng d00aComparison of the Effectiveness of Cream Extracts and VEGF Expression on Incision Wounds in Male Wistar Rats Treated with Ethanol Extracts of Papaya Leaf, Fruit Flesh, and Seeds (Carica Papaya L.)0 aComparison of the Effectiveness of Cream Extracts and VEGF Expre cJanuary 2025 a28-390 v173 a

Background: Papaya (Carica papaya Linn) is a tropical fruit plant known for its medicinal benefits, including wound healing. Objective: This study aimed to analyze and compare the potential of papaya leaf, fruit, and seed extracts in accelerating incision wound healing in male Wistar rats. Additionally, we compared the flavonoid content and stability of the extracts in cream formulations. Materials and Methods: Creams containing 30% ethanol extracts of papaya leaf, fruit, and seeds were prepared and applied to the backs of male Wistar rats for two weeks. The wound diameter, epithelial thickness, fibroblast count, macrophage count, collagen density, and VEGF expression were measured after two weeks. Results: Our findings revealed no significant differences between the effects of the papaya leaf, fruit, and seed ethanol extracts on wound diameter, epithelial thickness, fibroblast count, macrophage count, and collagen density (p > 0.05). There were also no significant differences when compared to the negative control group (p > 0.05). The highest flavonoid content was found in the ethanol extract of papaya leaves. Application of the ethanol extract creams of leaf, fruit, and seeds had a significant effect on angiogenesis, as evidenced by VEGF expression (p = 0.002). Conclusion: Papaya leaf, fruit, and seed extracts are promising products for wound healing. Further research is recommended to conduct periodic histopathological examinations during the wound healing process and to explore different extract concentrations for optimal results.

10aIncision wound; Male Wistar rats; Papaya; VEGF1 aNasution, Ali, Napiah1 aTiojaya, Juanto1 a1 aTandanu, Erny1 aSuandy, Suandy1 aBudi, Andre1 aNasution, Masdalena uhttps://phcogj.com/article/2463