04941nas a2200361 4500008004100000245010400041210006900145260001700214300001000231490000700241520381000248653001404058653002004072653001604092653002504108653001404133653003504147100002704182700002204209700002704231700003104258700002504289700002704314700002504341700003104366700002404397700002604421700002304447700002204470700002604492700002504518856003604543 2025 eng d00aMedicinal Application of the Iceland Poppy (Papaver nudicaule L.) in Traditional Mongolian Medicine0 aMedicinal Application of the Iceland Poppy Papaver nudicaule L i cJanuary 2025 a71-760 v173 a

In recent years, there has been a considerable focus on the utilization of natural medicinal substances, including plant-based medicines and formulations. While traditional medicine has been utilizing various medicinal plants to treat a wide range of diseases, there are still many medicinal plants and substances that have not been thoroughly studied at the scientific level. One such plant is the Iceland poppy (Papaver nudicaule L.) from the Papaveraceae family. Globally, the Papaveraceae family comprises 44 genera and 760 species of which 32 species, representing 7 genera, are identified within Mongolia. The Iceland poppy (Papaver nudicaule L.) is extensively distributed throughout Mongolia, with all parts of the plant, including its fruit and flowers. In addition, it has been traditionally employed in Mongolian medicine to treat a variety of ailments. However, systematic research on the practical applications and studies of the status of the local Iceland poppy in both modern and traditional Mongolian medicine remains poorly reported. Therefore, we aim to conduct a comprehensive and comparative study of the Iceland poppy (Papaver nudicaule L.) and its application in the Traditional Mongolian medicinal literature and internationally published studies. Materials and Methods: In this study, data was collected from a comprehensive review of the international and Traditional Mongolian medicine literature to understand the medicinal application of the Iceland poppy. Additionally, current study results were analyzed to assess its practical applications and efficacy in modern medicinal contexts. Results: "In a variant of Mongolian medicinal prescriptions, the Iceland poppy (Papaver nudicaule L.) is combined with the herb “Govo jad-5” Mongolian traditional prescription for treating surgical wounds, torn blood vessels, and both old and new wounds. Furthermore, the book 'Methods and Prescriptions for Using Medicinal Plants in Traditional Mongolian Medicine reports that Iceland poppy is part of a mixture of four types of poppies used to treat conditions such as diarrhea, intestinal inflammation, and dysentery, by boiling and administering the concoction. A study by Otgonpurev Sukhbaatar et al., (2018) determined that the optimal conditions for callus and suspension biomass production of Papaver nudicaule L. are 1 mg/L naphthalene acetic acid and 0.5 mg/L benzyl adenine in MS media. Additionally, Gerelt-Od Yadamsuren et al., reported that the alkaloids 8,14-dihydroamurin, 8,14-dihydroflavinantin, and flavinantin from Papaver nudicaule L. exhibit significant antiviral activity against human rhinovirus-14. Conclusion: Iceland poppy (Papaver nudicaule L.) has been used in traditional Mongolian medical practice for a long time. it has been historically widely used in Mongolian traditional medicine to treat wounds under the name of “wound healer”. As reported by the scientific literature, the primary uses of these plants include inhibiting acetylcholinesterase enzyme, anti-cancer effects, as well as antioxidant and anti-inflammatory properties. Furthermore, regarding its chemical composition, researchers have conducted studies that confirm the presence of alkaloids in this plant, specifically isoquinoline alkaloids. These compounds are known for their diverse biological activities and potential therapeutic effects, which may contribute to the plant's traditional medicinal uses. In summary, the Iceland poppy (Papaver nudicaule L.) has been utilized in traditional medicine for treating a variety of illnesses; however, it suggests that more comprehensive research is necessary to scientifically substantiate these applications.

10aAlkaloids10aMedicinal plant10aNudicaulins10aPapaver nudicaule L.10aProtopine10aTraditional Mongolian medicine1 aBayarsaikhan, Enkhtuul1 aDamba, Turtushikh1 aErdenebat, Buyanjargal1 aRyenchinbyambaa, Norovnyam1 aDaramzav, Otgonsuren1 aBattulga, Khuvitavilan1 aBoldbaatar, Munkhzul1 aBadamtsetseg, Myagmarsuren1 aDorjval, Enkhjargal1 aDamdinjav, Davaadagva1 aUrjin, Otgonbaatar1 aHalabalaki, Maria1 aKukula-Koch, Wirginia1 aKhurelbat, Daariimaa uhttps://phcogj.com/article/2473