02624nas a2200205 4500008004100000245018800041210006900229260001600298300001200314490000700326520188200333653001502215653002702230653002002257653001902277100003202296700003002328700002402358856003602382 2025 eng d00aAnti-aging Efficacy and Safety of Topical Application of Two Standardized Fenugreek Seed Extracts on Facial Skin in Women: Randomized, Double-Blind, Placebo-Controlled, Clinical Study0 aAntiaging Efficacy and Safety of Topical Application of Two Stan cAugust 2025 a470-4790 v173 a

Introduction: Fenugreek (Trigonella foenum graecum L.) is widely used in culinary and medicinal applications and has recently gained attention for its potential anti-aging properties. Objectives: This randomized, double-blind, placebo-controlled study evaluated the anti-aging efficacy and safety of topical application of flavonoid glycosides-based and eleutheroside-oligosaccharide-based standardized fenugreek seed extract creams, namely INDUS1520 and INDUS1530, respectively. Methods: Seventy-five healthy women aged between 35 and 55 years with mild to moderate facial wrinkles were randomly allocated to receive either INDUS1520, INDUS1530, or a Placebo cream for 60 days. Efficacy outcomes included skin luminescence, color, trans-epidermal water loss, moisture content, gloss, elasticity, firmness, wrinkle depth, surface roughness, and collagen distribution. Safety was assessed using a dermatological assessment and subject-reported intolerance questionnaire for adverse events. Results: INDUS1530 significantly improved skin hydration and wrinkle depth, while INDUS1520 significantly reduced transepidermal water loss compared with Placebo. Both creams showed a trend of decreased skin roughness and increased collagen distribution, although this difference was not statistically significant between the groups. All treatments, including Placebo, increased skin gloss. No adverse events or skin irritation were observed. Conclusions: Both fenugreek seed extract creams were well tolerated and demonstrated potential anti-aging benefits, with INDUS1530 showing more pronounced effects on skin hydration and wrinkle reduction. These findings support the use of standardized fenugreek seed extracts as safe and effective ingredients in anti-aging skin care products.

10aAnti-aging10aFenugreek seed extract10aSkin elasticity10aSkin hydration1 aThakurdesai, Prasad, Arvind1 aDeshpande, Pallavi, Onkar1 aNimse, Savita, Raju uhttps://phcogj.com/article/2526