01923nas a2200265 4500008004100000245012300041210006900164260001900233300001200252490000700264520113500271653001901406653001601425653001001441653001101451653001001462653002301472100001601495700002901511700001701540700003101557700002001588700001301608856003601621 2025 eng d00aAcute Oral Toxicity Evaluation of Hydroalcoholic Extract of Salvia Officinalis Roots in Wistar Rats as per OECD 423 TG0 aAcute Oral Toxicity Evaluation of Hydroalcoholic Extract of Salv cSeptember 2025 a577-5820 v173 a

Background: In this study, we assessed the hydroalcoholic root extract of Salvia officinalis oral acute toxicity investigation using an animal model. Methods: The investigation of acute oral toxicity was conducted using OECD 423 guidelines. The Institutional Animal Ethics Committee approved the study (IAEC). A single oral dose of Salvia officinalis hydroalcoholic root extract (800, 1600, and 3200 mg/kg) was administered, and the subjects were monitored for 14 days. Animals were sacrificed on the fifteenth day, and body weight, haematological, and serum hepatic biochemical parameters were assessed and compared to the standard group. Results:Groups treated with Salvia officinalis showed no mortality or discernible alterations. The findings show that Wistar rats did not experience appreciable harmful effects from administering hydroalcoholic root extract from the Salvia officinalis plant. Conclusions: The extract can be utilized safely for therapeutic use in pharmaceutical formulations.

10aAcute toxicity10aHaematology10aheart10aKidney10aLiver10aSalvia officinalis1 aHS, Ranjini1 aAzar, Kadmad, Abdul Hame1 aHaq, Fayazul1 aGoudappala, Prashanthkumar1 aHR, Vinodakumar1 aA, Akash uhttps://phcogj.com/article/2539