02549nas a2200229   4500008004100000245014500041210006900186260001800255300001200273490000700285520181200292653002202104653001602126653002202142653001402164653002102178653002002199100002802219700001802247700001802265856003602283       2025                        eng d00aProtective Role of Centella asiatica Extract Against Carbon Tetrachloride–Induced Hepatic Damage: A Biochemical and Ultrasonographic Study0 aProtective Role of Centella asiatica Extract Against Carbon Tetr  cDecember 2025  a760-7690 v173 a<p class="rtejustify">This study aimed to evaluate the hepatoprotective activity of <em>Centella asiatica</em> extract on Wistar rats induced with carbon tetrachloride (CCl<sub>₄</sub>). The extract is known to contain active compounds such as flavonoids, phenolics, and triterpenoids, which contribute to its antioxidant and anti-inflammatory effects. The total phenolic and flavonoid contents were 70.31 mg GAE/g and 13.49 mg QE/g, respectively, with very strong antioxidant activity (IC<sub>₅₀</sub> = 48.45 ppm). Evaluation through ultrasonography and histopathology revealed structural improvement in the liver of treated groups, particularly at doses of 200 and 300 mg/ kgBW, marked by reduced abnormal echogenicity and improved liver parenchyma, along with a decrease in histopathological score from 2 to 1. The administration of the extract also significantly reduced proinflammatory cytokines TNF-α and IL-6 (P≤0.05), as well as CRP levels, indicating strong anti-inflammatory potential. In addition, liver function showed meaningful recovery, with the highest albumin level recorded at 200 mg/kgBW (3.00 ± 0.52 g/dL), and a significant reduction in bilirubin level at 300 mg/kgBW to 0.102 ± 0.040 mg/dL. Significant decreases were also observed in SGOT and SGPT enzyme levels in the treatment groups, especially at 300 mg/kgBW, indicating protection of hepatocyte integrity. In conclusion, this study demonstrated that Centella asiatica extract possesses hepatoprotective effects through antiinflammatory, antioxidant, and liver function-restorative mechanisms. These findings support the potential development of pegagan as a phytopharmaceutical agent for adjunct therapy in liver disorders and highlight the need for further studies on its active compounds and long-term safety.</p>
10aAnti-inflammatory10aAntioxidant10aCentella asiatica10aCytokines10aHepatoprotective10aUltrasonography1 aPulungan, Ica, Yulianti1 aGirsang, Ermi1 aGirsang, Ermi  uhttps://phcogj.com/article/2566