02387nas a2200277 4500008004100000245009000041210006900131260001800200300001200218490000700230520156800237653002201805653001601827653002001843653002101863653002801884653002401912100001801936700001901954700002801973700001702001700002102018700001502039700001902054856003602073 2025 eng d00aAntioxidant and Neuroprotective Potential of Ashwagandha In Aluminum-Induced Toxicity0 aAntioxidant and Neuroprotective Potential of Ashwagandha In Alum cDecember 2025 a336-3410 v173 a

Introduction : Aluminium is the most abundant metal and the third most common element in the Earth’s crust, following oxygen and silicon. Exposure to aluminium is associated with oxidative damage, primarily due to its ability to disrupt redox balance, generate reactive oxygen species, and impair antioxidant defense mechanisms.This study was aimed to find the potential role of ashwagandha on aluminium induced brain toxicity. Methods: In the present study rats were grouped into 4 groups of 6 rats in each. Brain tissue was removed and processed for biochemical and histopathological analysis. Results: In the present study, administration of aluminium to rats resulted in a significant decrease in tissue GSH levels and a corresponding increase in MDA levels in the aluminium-treated group compared to the normal control.. Treatment with Ashwagandha showed a significant increase in GSH level and decrease in MDA level. Photomicrographic sections of the Brain in Ashwagandha-treated rats showed normla neuronal Count and exposure to Aluminium has caused significant reduction in the neuronal count. Experimental group pretreated with ashwagandha showed a visible increase in neuronal count in different regions of the rat brain. Conclusion: The results revealed that oral administration of aluminium induced adverse oxidative effects in the exposed animals, while treatment with Ashwagandha markedly reduced the extent of aluminium chloride-induced brain injury.

10aAluminum Chloride10aAshwagandha10aMalondialdehyde10aOxidative stress10aReactive Oxygen Species10aReduced glutathione1 aBabu, Anchana1 aKini, Rekha, D1 aKumar, Nayanatara, Arun1 aGokul, Megha1 aBlossom, Vandana1 aP, Sreerag1 aNayak, Shymala uhttps://phcogj.com/article/2575