02808nas a2200277   4500008004100000245016400041210006900205260001500274300001100289490000700300520193300307653002302240653001302263653001902276653002102295653001202316100001902328700001702347700002102364700002302385700002702408700002002435700002302455700001602478856003602494       2026                        eng d00aNutritional and Phytochemical Characterization of Moringa oleifera Leaves from an Arid Region: LC-MS and AAS-based Profiling for Potential Dietary Applications0 aNutritional and Phytochemical Characterization of Moringa oleife  cApril 2026  a94-1010 v183 a<p class="rtejustify"><strong>Background:</strong> <em>Moringa oleifera</em> (MO), widely recognized for its exceptional nutritional value and therapeutic properties, has attracted considerable scientific interest. However, the specific bioactive phytochemicals associated with its potential effects in the treatment of hyperlipidemia and obesity remain insufficiently elucidated. <strong>Objective:</strong> This study aimed to evaluate the nutritional, therapeutic, and antioxidant potential of <em>Moringa oleifera</em> leaves (MOL) from the Ghardaïa region (Southern Algeria) using hydromethanolic (HME) and aqueous (AE) extracts. <strong>Materials and methods:</strong> Proteins and carbohydrates contents were quantified using Bradford and DuBois et al.methods respectively. Mineral content was determined using atomic absorption spectrometry (AAS). Bioactive profiles were identified by Ultra-performance liquid chromatography (UPLC-ESI-MS/MS), alongside antioxidant capacity using Ferric Reducing Antioxidant Power (FRAP) assay. <strong>Results: </strong>HME exhibited higher protein (19.34 ± 1.48 g/100 g), while AE contained elevated total sugars (32.24 ± 1.11 g/100 g). Mineral analysis revealed significant iron (59.07 mg/100 g), magnesium (250.72 mg/100 g), and manganese (7.08 mg/100 g). UPLC-ESI-MS/MS identified 28 bioactive compounds, with Quercetin-3-glucoside (47.91%) and myricetin (17.47%) as dominant flavonoids, alongside curcumin (11.21%) and β-carotene (4.2%). Ferthermore, AE exhibited significantly higher FRAP values than HME, with IC<sub>50</sub> values of 207.09 ± 2.31 μg/mL and 266.23 ± 3.63 μg/mL, respectively. <strong>Conclusions:</strong> This initial report highlights MOL extracts as a sustainable and cost-effective dietary supplement for managing hyperlipidemia and obesity, due to their rich nutrient content, diverse bioactive compounds, and adaptability to arid climates.</p>
10aDietary supplement10aGhardaia10aHyperlipidemia10aMoringa oleifera10aObesity1 aKedaid, Hafida1 aToumi, Ikram1 aKraimat, Mohamed1 aAdamou, Abdelkader1 aMahamedi, Alla, Eddine1 aRahmani, Youcef1 aImelhayene, Meriem1 aTelli, Alia  uhttps://phcogj.com/article/2595