02456nas a2200265 4500008004100000245020600041210006900247260001400316300001200330490000700342520153800349653001401887653002101901653001401922653001601936653002901952653002001981100002402001700002102025700002802046700002402074700002902098700002702127856003602154 2026 eng d00aEffects of Hydrolyzed Marine Collagen Peptide Supplementation Combined with Phytonutrients on Skin Biophysical Parameters and Extracellular Matrix Biomarkers in Thai Women: A Prospective Clinical Study0 aEffects of Hydrolyzed Marine Collagen Peptide Supplementation Co cJune 2026 a157-1630 v183 a

Background: Skin aging involves progressive deterioration of extracellular matrix components. This study investigated the effects of hydrolyzed marine collagen peptide supplementation combined with phytonutrients on skin biophysical parameters and dermal biomarkers in Thai women. Methods: Sixtythree Thai women aged 40–60 years received daily supplementation (10,000 mg marine collagen peptides, Chlorella, grape seed extract, rice ceramides) for 12 weeks. Assessments included Antera 3D imaging, Cutometer elasticity measurements, Tewameter barrier function evaluation, and Corneometer hydration analysis. A subset (n=20) underwent suction blister biopsy for dermal biomarker analysis. Results: Significant improvements were observed in Cutometer parameters: R5 net elasticity (p<0.001), R6 viscoelasticity (p=0.018), and R7 biological elasticity (p=0.003). Transepidermal water loss (TEWL) decreased by 12.1% (p=0.007). Antera 3D analysis revealed a significant increase in wrinkle width (p=0.021), indicating wrinkle flattening. Biomarker analysis showed significant increases in fibrillin-1 (+8.34%, p=0.005) and biglycan (+22.91%, p=0.036). Glogau photoaging classification improved in 23.8% of participants. Conclusions: Marine collagen peptide supplementation combined with phytonutrients significantly improved skin elasticity and barrier function, with molecular evidence of extracellular matrix enhancement in Thai women.

10aAntera 3D10aBarrier function10aCutometer10aFibrillin-110aMarine collagen peptides10aSkin elasticity1 aVichaidit, Uratchat1 aPhetkate, Pratya1 aTungsukruthai, Parunkul1 aPawa, Kammal, Kumar1 aChakkavittumrong, Panlop1 aKamalashiran, Chuntida uhttps://phcogj.com/article/2606