02574nas a2200217   4500008004100000245011200041210006900153260001600222300001200238490000600250520187800256653002502134653002702159653002802186653000902214653002502223100002302248700002202271700002502293856003802318       2017                        eng d00aAntioxidant Activity, Biochemical Components and Sub-Chronic Toxicity of Different Brown Rice Kefir Powders0 aAntioxidant Activity Biochemical Components and SubChronic Toxic  cApril 2017   a388-3940 v93 a<p style="text-align: justify;"><strong>Aims:</strong> This study aimed to investigate and compare antioxidant activity, biochemical components and subchronic toxicity of brown rice kefir powder from three different coloured rice varieties; Khao Dawk Mali 105 (KDMLKP, white), Red Hawm (RHKP, red), and Hawm Nil (HNKP, dark purple), with cow milk kefir powder (CMKP). <strong>Medthods:</strong> Antioxidant activity performed by using ferric reducing antioxidant power (FRAP) assay and 2, 2&acute;-diphenyl-1-picrylhydrazyl (DPPH) assay. Biochemical components values including gamma-aminobutyric acid and alpha-tocopherol were determined using high performance liquid chromatography, but total phenolic compounds was detemined using the Folin-Ciocalteu reagent. Sub-chronic toxicity test, KDMLKP, RHKP and HNKP at the doses of 150 mg/kg were given orally to the rats every day for 90 days. <strong>Results:</strong> Antioxidant activity showed that brown rice kefir powders were significantly (p&le;0.05) higher than cow milk kefir powder. Interestingly, HNKP provided the highest FRAB value and the lowest IC<sub>50</sub> of DPPH assay. HNKP had also the highest biochemical component values. Repeat administration of KDMLKP, RHKP and HNKP did not produce any symptoms of sub-chronic toxicity; mortality, hematological values, and blood biochemistry in the rats. Moreover, RHKP produced HDL increasing without CHO, TG and LDL changing in rats. <strong>Conclusions:</strong> These data indicate that brown rice kefir powders show no sub-chronic toxicity and exhibit more antioxidant activity and biochemical component values than cow milk kefir powder. Surprisingly, RHKP showed HDL increasing while HNKP had the highest potent antioxidant activity and biochemical components. Thus, both rice kefir powders are safe and probably a new biochemical resource for health.</p>`10aantioxidant activity10aBiochemical Components10aBrown Rice Kefir Powder10aRice10aSub-Chronic Toxicity1 aChunchom, Supaporn1 aTalubmook, Chusri1 aDeeseenthum, Sirirat  u/files/PJ-9-3/10.5530pj.2017.3.66