02978nas a2200265   4500008004100000245012600041210006900167260001300236300001200249490000600261520213700267653001702404653002102421653001802442653002502460653003002485653001002515653001102525100003302536700002402569700002902593700002902622700002302651856003802674       2017                        eng d00aChemical Profile and Biological Activities of Essential oil of Aerial parts of Artemisia monosperma Del. Growing in Libya0 aChemical Profile and Biological Activities of Essential oil of A  cMay 2017  a578-5860 v93 a<p style="text-align: justify;"><strong>Background:</strong> From the bioactivity stand point <em>Artemisia monosperma</em> Del. is reputed to have antispasmodic and anthelmintic properties. Various types of secondary metabolites were reported in A. <em>monosperma </em>plants from different localities. <strong>Objective:</strong> The current study was planned aiming to investigate the influence of stage of development on the composition, antimicrobial, antiinflammatory and antioxidant activities of the essential oil derived from the aerial parts of the Libyan plants. <strong>Material and Methods:</strong> A. <em>monosperma</em> volatiles were hydro-distilled from aerial parts of Libyan plants, collected at different stages of growth: before flowering (A1), and at beginning (A2) and by the end (A3) of flowering stage. Yields ranged from 0.16-0.26 ml/100g fresh material (A3, highest). GC/FID and GC/MS analyses were performed. <strong>Results:</strong> Among 16-20 identified components (97.63-99.00% of total composition), 11 were common in all samples. A1 and A2 showed close amounts of hydrocarbons (63.56 and 66.55%), but lesser than A3 (88.36%); monoterpenoids were mainly represented by sabinene (13.15-22.85%), &beta;-pinene (9.00-24.03%) and &beta;-cis-ocimene (3.73-12.92%); while sesquiterpenoids appeared absent. Among oxygenated components (11.29, 31.08 and 35.44 % in A3, A2 and A1), bornyl acetate was the major monoterpenoid (8.00-31.00%, highest in A1); and the sesquiterpenoid, &beta;-eudesmol (8.01%) was detected in A2 only. Moreover, A2 demonstrated significant antifungal effect against <em>Aspergillus fumigatus</em> and <em>Geotricum candidum </em>(MIC 0.98 and 0.24 &mu;g/ml). <strong>Conclusion:</strong> A3 exerted the highest anti-inflammatory activity as compared to the other volatiles. A1 restored the reduced blood GHS level in diabetic animals almost as efficiently as Vitamin E. The antioxidant activity of the volatiles is decreased during the flowering stage, being the highest before flowering (A1); this could be associated to the decreasing bornyl acetate content of the samples.</p>10aAnti-oxidant10aAntiinflammatory10aAntimicrobial10aArtemisia monosperma10aEssential oil composition10aGC-MS10aLibya.1 aZalabani, Soheir, Mohamed El1 aTadros, Soad, Hanna1 aSayed, Abeer, Mohamed El1 aDaboub, Areej, Almaktouf1 aSleem, Amany, Amen  u/files/PJ-9-4/10.5530pj.2017.4.92