02534nas a2200217   4500008004100000245013100041210006900172260001900241300001200260490000600272520182300278653001802101653001602119653002602135653002502161653002402186100002202210700002502232700002402257856003502281       2017                        eng d00aPhotodynamic Toxicity of Chlorophyllin against Fasciola gigantica Carrier Snail Indoplanorbis exustus in Visible Spectral Band0 aPhotodynamic Toxicity of Chlorophyllin against Fasciola gigantic  cSeptember 2017  a729-7360 v93 a<p style="text-align: justify;"><strong>Background:</strong> Fasciolosis is one of the most debilitating diseases caused by liver flukes <em>Fasciola hepatica and F. gigantica</em>. Snail Lymnaeidae and Planorbidae is the intermediate host of these flukes. Snail population management is a good tool to control fasciolosis because gastropods represent the weakest link in the life-cycle of trematode. Aim of the present study is to explore the molluscicidal activity of chlorophyllin in visible spectral band against <em>Fasciola gigantica carrier snail Indoplanorbis exustus</em>. <strong>Methods:</strong> Chlorophyll was transformed into water-soluble chlorophyllin in 100% ethanol by using different types of chemicals. Ten snails <em>Indoplanorbis exustus</em> were placed in a glass aquarium containing 3 L of dechlorinated tap water. These snails were treated with different concentrations of chlorophyllin in sunlight as well as exposed to different visible spectral band of light. <strong>Results:</strong> Pure chlorophyllin (96 h LC<sub>50</sub> 6.54 mg/l) in sunlight was more toxic than extracted chlorophyllin (96 h LC<sub>50</sub> 939.65 mg/l). There was a significant variation in the toxicity of chlorophyllin with snails, exposed to visible spectral band of light. The highest and lowest toxicity of chlorophyllin against <em>I. exustus</em> was noted in yellow light (96 h LC<sub>50</sub> 2016.79 mg/l) and green light (96 h LC<sub>50</sub> 2433.16 mg/l). High performance liquid chromatography (HPLC) study reveals that the active molluscicidal component extracted in spinach leaves is chlorophyllin. <strong>Conclusion:</strong> Due to the photodynamic nature of chlorophyllin, it has the potential to control the population of vector snails and ultimately fasciolosis in developing countries.</p>10aChlorophyllin10aFasciolosis10aIndoplanorbis exustus10aPhotodynamic Product10aVisible light band.1 aChaturvedi, Divya1 aSingh, Dinesh, Kumar1 aSingh, Vinay, Kumar  uhttp://fulltxt.org/article/168