02213nas a2200217 4500008004100000245019700041210006900238260001900307300001200326490000600338520144500344653001201789653002401801653003101825653001601856100002001872700001901892700002501911700002401936856003501960 2017 eng d00aTo Evaluate the Antidiabetic and Rejuvenating Capability of Tissues on Alloxan Induced Diabetic Rats under the Effect of Ethanolic Leaf Extract of Coriandrum sativum: A Histopathological Study0 aTo Evaluate the Antidiabetic and Rejuvenating Capability of Tiss cSeptember 2017 a792-7980 v93 a

Objective: To evaluate the antidiabetic and rejuvenating capability of tissues on alloxan induced diabetic rats under the effect of ethanolic leaf extract of Coriandrum sativum. Methods: Diabetic model was prepared by administration of alloxan monohydrate (150 mg/ kg i.p). The ethanolic leaf extracts of Coriandrum sativum at a dose of 200 and 400 mg/kg of body weight were administrated to diabetic induced groups for a period of 28 days. The effect of ethanolic leaf extract of Coriandrum sativum leaf extract on serum blood glucose, insulin, lipase, α- amylase and LDH as well as kidney function test [urea, uric acid, albumin, protein and creatinine] were measured in the alloxan induced diabetic rats. Results: In the acute toxicity study, ethanolic leaf extract of Coriandrum sativum leaf was non-toxic at 2 000 mg/kg in rats. The increased insulin level, albumin and protein level, decreased blood glucose and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of Coriandrum sativum leaf compared to diabetic control rats. In Histopathological study were revealed toward normal. Conclusion: Ethanolic extract of Coriandrum sativum leaf possesses significant antidiabetic and rejuvenating capability of tissues.

10aAlloxan10aCoriandrum sativum.10aPancreas and Kidney Tissue10aWistar Rats1 aSharma, Bhaskar1 aSharma, Gaurav1 aJoshi, Suresh, Chand1 aSingh, Sunil, Kumar uhttp://fulltxt.org/article/177