02225nas a2200205 4500008004100000245013800041210006900179260001900248300001200267490000600279520155300285653002901838653001801867653001401885653001501899653002701914100001701941700002601958856003501984 2017 eng d00aToxicity Assessment and Evaluation of Analgesic, Antipyretic and Anti-Inflammatory Activities on Cordia obliqua Leaf Methanol Extract0 aToxicity Assessment and Evaluation of Analgesic Antipyretic and  cSeptember 2017 a856-8610 v93 a

Background: Cordia obliqua Willd. Plant belongs to genus Cordia and family Boraginaceae. Commonly it is known as Clammy Cherry and in Hindi Lasora. Earlier very few researches were carried out to explore its medicinal importance as compared with other Cordia species. Objective: To determine maximum safe dose and explore analgesic, anti-inflammatory and antipyretic activities of Cordia obliqua leaf methanol extract. Materials and Methods: As per our previous study report, the leaf methanol extract is rich in phyto-constituents and has good antioxidant effect; so only methanol extract was studied here. The maximum safe dose of methanol extract was found by acute oral toxicity study according to OECD guidelines 423. For analgesic effect, hot plate and tail flick method, for anti-inflammatory, Carageenan induced rat paw edema and for antipyretic study, yeast induced pyrexia method were used. Results: The extract dose up to 2000mg/Kg was found safe with no any side effects. Three dose levels were tested for all activities. The medium (250 mg/Kg) and high (500 mg/Kg) dose of methanol extract was found effective in all activities when compared with standard. The result for antipyretic activity was found better than other activities. Conclusion: It can be concluded that Cordia obliqua leaf is safe and effective drug for relief of pain, fever and inflammation.

10aCarageenan induced edema10aClammy Cherry10aHot plate10aTail flick10aYeast induced pyrexia.1 aGupta, Richa1 aGupta, Ghanshyam, Das uhttp://fulltxt.org/article/187