01354nas a2200205 4500008004100000245009300041210006900134260001800203300001000221490000700231520071900238653002300957653002400980653001701004653001401021653001901035100002101054700003801075856003501113 2018 eng d00aAngiotensin-Converting Enzyme Inhibition of Fractions from Eleusine indica Leaf Extracts0 aAngiotensinConverting Enzyme Inhibition of Fractions from Eleusi cDecember 2017 a25-280 v103 a
Solvent fractions and decoction of Eleusine indica leaves were tested for their ability to inhibit angiotensin-converting enzyme (ACE), an important component of the Renin-Angiotensin- Aldosterone System which is a critical regulator of arterial blood pressure. The ACE inhibitory activity of each fraction was measured by employing a colorimetric assay based on the hydrolysis of histidyl-hippuryl-leucine (HHL) by ACE. Preliminary assay results revealed that the ethyl acetate fraction exhibited the highest antihypertensive activity with a percent inhibition of 51.51%. This fraction was considered for further isolation using a bioassay-guided fractionation scheme.
10aBioactive extracts10aHigh-blood pressure10aHypertension10aMedicinal10aPlant extracts1 aTutor, Jasmin, T1 aChichioco-Hernandez, Christine, L uhttp://fulltxt.org/article/360