02510nas a2200301 4500008004100000245022800041210006900269260001800338300001200356490000700368520143000375653002401805653001801829653001501847653001501862653002501877653002001902100002101922700003101943700002801974700002802002700003102030700002302061700003402084700003002118700002502148856003502173 2018 eng d00aNephroprotective Activity of Methanolic Extract of Lantana camara and Squash (Cucurbita pepo) on Cisplatin-Induced Nephrotoxicity in Rats and Identification of Certain Chemical Constituents of Lantana camara by HPLC-ESI- MS0 aNephroprotective Activity of Methanolic Extract of Lantana camar cDecember 2017 a136-1470 v103 a

Introduction: Cisplatin is a highly effective chemotherapeutic agent; its clinical use is severely limited by serious side effects as nephrotoxicity. The aim of this study is to evaluate the nephroprotective activity of defatted methanolic extract of two Egyptian plants: Lantana camara and Cucurbita pepo and certain fractions derived from the defatted methanolic extract of L. camara on cisplatin-induced nephrotoxicity in rats. Also, identification of certain chemical constituents of L. camara by HPLC-ESI- MS. Methods: Nephrotoxicity was induced in rats by single dose of cisplatin. The effect of plants extract at doses 100-400 mg/kg.b.wt comparing with standard; ascorbic acid; was determined using serum urea, creatinine and some ions. Furthermore, the effect of these extracts on some renal antioxidant enzymes and histopathological examination of kidneys were examined. Results: The defatted methanolic extract and ethyl acetate fraction of L. camara showed the highest improvement of renal parameters. Also, HPLC-ESI-MS analysis of L. camara extracts exhibited bioactive phenolic compounds including phenyl ethanoid, flavonoids and phenolic acids. Conclusion: The phytochemical constituents of L. camara are responsible for their nephroprotective activity.

10aAntioxidant enzymes10aAscorbic acid10aCreatinine10aFlavonoids10aHistological studies10aPhenyl etanoid.1 aAbdel-Hady, Heba1 aEl-Sayed, Mortada, Mohamed1 aAbdel-Hady, Afaf, Ahmed1 aHashash, Maher, Mahmoud1 aAbdel-Hady, Ahmed, Mohamed1 aAboushousha, Tarek1 aAbdel-Hameed, El-Sayed, Saleh1 aLateef, Ezzat, El-Sayed A1 aMorsi, Eman, Abdalla uhttp://fulltxt.org/article/410