02717nas a2200217 4500008004100000245011700041210006900158260001700227300001200244490000700256520200400263653001302267653002402280653003202304653003002336653002402366100002702390700002402417700002302441856003502464 2018 eng d00aMaltase Inhibitory Activity of Aqueous Extracts of Zingiber officinale Rosc. and Trigonella foenum-graecum Linn.0 aMaltase Inhibitory Activity of Aqueous Extracts of Zingiber offi cJanuary 2018 a226-2290 v103 a

Context: An important approach to diabetes treatment involves the regulation of postprandial hyperglycemia by delaying the release of glucose into the bloodstream using inhibitors for carbohydrate digesting enzymes such as maltase. Current synthetic antidiabetic drugs are associated with side effects that have restricted their usage. Antidiabetic plants such as Zingiber officinale and Trigonella foenum-graecum, commonly used as medicinal herbs in India, provide an attractive alternative as a source of maltase inhibitors. Aim: This study aimed to determine maltase inhibitory activity in antidiabetic plants in comparison with that of a synthetic drug, Acarbose, used as a positive control. Study Design: In vitro Enzyme Inhibition Assay. Materials and Methods: Aqueous plant extracts were prepared using rhizome of Z. officinale and leaves of T. foenum-graecum. Varying concentrations of the aqueous plant extract were tested for maltase inhibitory activity using crude yeast maltase enzyme. Statistical Analysis: Unpaired, two tailed t-test was used to detect the significant difference between the mean maltase enzyme activity of the control and that of the test. Results: The aqueous extract of T. foenum-graecum exhibited a higher potent maltase inhibitory activity with IC50 value of 1.05% as compared to that of the aqueous extract of Z. officinale with IC50 value of 2.13%. Acarbose showed the highest potency of maltase inhibition with an IC50 value of 0.014%. Conclusion: Z. officinale and T. foenum-graecum have significant maltase inhibitory activity (p <0.05). Thus, a contributing factor to the antidiabetic property of the two plants may be attributed to their maltase inhibitory activity.

10aAcarbose10aAntidiabetic Plants10aMaltase Inhibitory Activity10aTrigonella foenum-graecum10aZingiber officinale1 aDamani, Janhavi, Jatin1 aPacha-Gupta, Radiya1 aMangalore, Nandita uhttp://fulltxt.org/article/469