02341nas a2200241 4500008004100000245016400041210006900205260001400274300001200288490000700300520155700307653001601864653001901880653001001899653001601909653002501925100002501950700002801975700002102003700001802024700002202042856003502064 2018 eng d00aHepatoprotective Potential of Trichosanthes dioica Roxb in Hepatotoxicity Induced by Simvastatin and its consequences on Biochemical and Haematological Indices0 aHepatoprotective Potential of Trichosanthes dioica Roxb in Hepat cJune 2018 a720-7240 v103 a

Objective:To evaluate hepatoprotective activity along with hematological and defensive recital of Trichosanthes dioica Roxb against simvastatin induced hepatotoxicity in experimental rodents. Methods: In the present study, in- vivo hepatoprotective effect of 50% methanolic fruit extract of Trichosanthes dioica Roxb (TME 200 and 400 mg/kg body weight) was evaluated using experimental model, simvastatin (20 mg/kg, p.o.), induced hepatotoxicity in experimental animals. The hepatoprotective activity was estimatedby interpreting using various biochemical parameters like SGOT, SGPT, ALP, total bilirubin, total protein and albumin along with the haematological and histopathological studies. Results: The treatment with TME significantly (P<0.05-P<0.001) and dose-dependently reversed simvastatin induced elevation in serum level ofSGOT, SGPT, ALP, total bilirubin and restored the total protein and albumin level. Furthermore, TME also signify the blood parameters at dose of 1000 and 2000 mg/kg and restored the body defense mechanism. The histological examination revealed that TME at dose of 200 mg/kg showed regeneration of hepatocytes around central vein with near normal liver architecture. Conclusion: The results of this study exhibited liver protective effect of Trichosanthes dioica Roxb against simvastatin induced liver injury and there by scientifically support its traditional use.

10aHepatocytes10aHepatotoxicity10aLiver10aSimvastatin10aTrichosanthes dioica1 aGupta, Ramesh, Kumar1 aSwain, Sudhansu, Ranjan1 aSahoo, Jagannath1 aGupta, Amresh1 aChaudhary, Sachin uhttp://fulltxt.org/article/658