02557nas a2200229   4500008004100000245015000041210006900191260001200260300001200272490000600284520182400290653001102114653002402125653001902149653001702168653002002185100001902205700002302224700002802247700001802275856003402293       2015                        eng d00aAnti-hyperglycemic and Anti-lipidemic activities of Diabac (a polyherbal formulation) in Streptozotocin-nicotinamide induced type 2 diabetic rats0 aAntihyperglycemic and Antilipidemic activities of Diabac a polyh  c01/2015  a283-2880 v73 a<p style="text-align: justify;"><strong>Aim:</strong> The objective of the work was to investigate the antidiabetic activity of Diabac (a polyherbal formulation) in streptozotocin-nicotinamide induced type 2 diabetic rats. <strong>Methods: </strong>Oral glucose tolerance test (OGTT) was performed to evaluate effect of Diabac on elevated glucose level. The type 2 diabetes was induced by overnight fasted rats by a single intraperitoneal (i.p.) injection of 65 mg/kg streptozotocin, 15 min. after the i.p. administration of 110 mg/kg nicotinamide. The diabetic rats were treated with Diabac (250, 500 and 1000 mg/kg, p.o.) or glibenclamide (5 mg/kg, p.o) for four week. Various parameters were studied such as fasting blood sugar level, serum insulin levels, glycated hemoglobin (HbA<sub>1C</sub>), serum lipid levels, se rum creatinine, urea, uric acid and liver glycogen. <strong>Results:</strong> Treatment with Diabac significantly reduced the blood sugar levels in OGTT. Diabetic rats showed a significant increase in the levels of glycated hemoglobin, serum lipids, serum creatinine, urea and uric acid, whereas there was a decrease in serum insulin, liver glycogen and HDL-C levels as compared to normal control rats. The administration of Diabac or glibenclamide significantly decreased the levels of glycated hemoglobin, TG, TC, LDL-C, serum creatinine, urea and uric acid, whereas there was an increase in the levels of liver glycogen and HDL-C as compared to diabetic control rats. However, the treatment with Diabac did not show any significant change in serum insulin levels as compared to diabetic control rats. <strong>Conclusion: </strong>These results of present study concluded that Diabac has anti-diabetic and anti-lipidemic activities which are responsible for its use in traditional medicine.</p>10aDiabac10aGlycated hemoglobin10aLiver glycogen10aSerum lipids10aStreptozotocin.1 aAgrawal, Richa1 aMaheshwari, Rajesh1 aBalaraman, Ramachandran1 aSeth, Avinash  uhttps://phcogj.com/article/69