02447nas a2200241 4500008004100000245010100041210006900142260001700211300001200228490000600240520166000246653001001906653001801916653002801934653002701962653002201989100002402011700003002035700003402065700003302099700003902132856003402171 2015 eng d00aComponent Authentication and Standardisation of an Anti-atherosclerotic Herbal Formulation-GSTC30 aComponent Authentication and Standardisation of an Antiatheroscl cNov-Dec 2015 a339-3430 v73 a

Context: Polyherbal drugs in traditional medicine have been time-tested for treatment of a wide variety of chronic ailments. Aims: To determine constituent components in an in-house designed polyherbal formulation GSTC3 and evaluation of consistency in preparation. Settings and Design: In this study, a hypolipidemic formulation was created using well known plant extracts such as Commiphora mukul (Hook. ex Stocks.) Eng. (Burseraceae), Salacia reticulata Wight (Celastraceae), Terminalia arjuna (Roxb.) Wight and Arn (Combretaceae) and Curcuma longa Linn (Zingiberaceae). Methods and Material: The authentication of individual plant powders was performed using techniques such as powder microscopy and characterised according to Ayurvedic pharmacopeia of India. Phytochemical screening, HPTLC analysis and physicochemical parameters were also determined. Results: The powder microscopic analysis of the individual components served as an authentication for source of plants used. Phytochemical screening ascertained that active classes of compounds reported in the individual extracts such as steroids, terpenoids and polyphenols came into the formulation. Finally, HPTLC analysis of three different batches of GSTC3 ensured stability and integrity in batch to batch preparations. Conclusion: Experimental studies have revealed the antioxidant, antiinflammatory, anti-lipidemic and anti-thrombotic efficacy of GSTC3. This standardisation procedure is essential for further development of GSTC3 into an efficient anti-atherosclerotic drug candidate

10aHPTLC10aPharmacognosy10aPhytochemical screening10aPolyherbal formulation10aPowder microscopy1 aManalil, Jeksy, Jos1 aSuseela, Indu, Muraleedha1 aRamavarma, Smitha, Koyickalma1 aNarayanankutty, Arunaksharan1 aRaghavamenon, Achuthan, Chathratti uhttps://phcogj.com/article/72