02419nas a2200217 4500008004100000245011500041210006900156260001800225300001200243490000700255520171800262653002201980653003202002653002202034653002702056653001802083100002202101700002002123700002302143856003502166 2018 eng d00aAmeliorative Effect of Moringa oleifera Fruit Extract on Reproductive Parameters in Diabetic-induced Male Rats0 aAmeliorative Effect of Moringa oleifera Fruit Extract on Reprodu cNovember 2018 as54-s580 v103 a

Background: Diabetes mellitus negatively impact the male reproductive parameters. The ability of Moringa oleifera fruit to improve the reproductive parameters in diabetic-induced male has yet to be documented. Aim: To investigate the anti-hyperglycaemic potential of M. oleifera fruit aqueous extract and its effect on reproductive parameters in diabetic-induced male rats. Materials and Methods: A total of 20 male Sprague Dawley rats were divided into four groups; normal control (without diabetic induction), negative control (diabetes without treatment), positive control (diabetes with metformin) and treatment group (diabetes with 500 mg/kg M. oleifera fruit aqueous extract). Treatments were given via oral gavage for 21 consecutive days. Analysis of fasting blood glucose level, sperm quality, testicular histology and relative testis weight were performed. Results: The administration of M. oleifera fruit aqueous extract exhibited a significant reduction in fasting blood glucose level and a pronounced increase in sperm quality (sperm count, motility, viability and morphology) compared with the negative control group. M. oleifera fruit extract restored the histology of the testes as they were seen to be packed with sperms and showed an organised spermatogenesis. The relative testis weight showed no significant difference between all groups. Conclusion: The results obtained suggested that M. oleifera fruit aqueous extract possessed an antihyperglycaemic property and improved the reproductive parameters in diabetic-induced rats

10aDiabetes mellitus10aFasting blood glucose level10aMale reproductive10aMoringa oleifera fruit10aSperm quality1 aKamalrudin, Amira1 aJasamai, Malina1 aNoor, Mahanem, Mat uhttps://phcogj.com/article/767