02267nas a2200241 4500008004100000245012900041210006900170260001700239300001000256490000700266520145100273653002201724653004901746653003301795653001801828653002301846100002101869700003101890700002701921700002001948700002201968856003501990 2019 eng d00aThe Anti-Angiogenic Properties of Morinda citrifolia. L (Mengkudu) Leaves Using Chicken Chorioallantoic Membrane (CAM) Assay0 aAntiAngiogenic Properties of Morinda citrifolia L Mengkudu Leave cJanuary 2019 a12-150 v113 a

Background: Anti-angiogenesis or inhibition of blood vessel formation is the best way to prevent the growth and metastasis of tumors. The use Morinda citrifolis. L extracts have been reported to exhibit a broad range of therapeutic effects, including antibacterial and antitumor. Objective: This study aims to investigate the anti-angiogenic properties of Morinda citrifolia. L leaves extracts using Chicken Chorioallantoic Membrane (CAM) assay. Materials and Methods: The Fertile White Leghorn eggs were divided into five groups which were control, Bevacizumab drug and treatment groups with 25%, 50% and 75% of Morinda citrifolia. L leaves extracts respectively. The reduction of the blood vessel was counted after 12 h and 24 h post-treatment. Results: Analysis have shown significant differences (P<0.05) in the reduction of the blood vessel between each group at 24 h post-treatment. The group with 75% extracts showed 37.1% reductions of blood vessel compared to groups 50% and 25% extracts which showed 4% and 12.8% respectively. The phytochemical screening has showed that Morinda citrifolia. L leaves extracts was positive for flavonoid, phenols and phytosterols. Conclusion: Morinda citrifolia. L leaves extracts consist of the phytochemical compounds that have the ability to inhibit the angiogenesis.

10aAnti-angiogenesis10aChicken Chorioallantoic Membrane (CAM) assay10aMorinda citrifolia. L leaves10aPhytochemical10aWhite Leghorn eggs1 aOthman, Zulhabri1 aKhalep, Hamimi, Rasyiqah H1 aAbidin, Azrina, Zainal1 aHassan, Halijah1 aFattepur, Santosh uhttps://phcogj.com/article/811