01960nas a2200169 4500008004100000245011500041210006900156260001500225300001000240520142000250653001301670653001301683653001801696653002201714653001901736856003501755 2019 eng d00aEffect of Porana paniculata Whole Plant on Blood Glucose Levels and Lipid Profile of STZ Induced Diabetic Rats0 aEffect of Porana paniculata Whole Plant on Blood Glucose Levels  cMarch 2019 axx-xx3 a

Background: To establish the antidiabetic potential of Porana paniculata whole plant belongs to Convolvulaceae family. Methods: Extraction and preliminary phytochemical screening were conducted by standard methods. Antidiabetic activity was evaluated by streptozotocin induced diabetic rats where the hydroalcoholic extract of plant was administered orally at a dose of 250 and 500 mg/kg for 30 days. Blood glucose levels were estimated at 1st, 10th, 20th and 30th day of study. Lipid profile was studied 30th day of study and body weight of the animals was measured at day 1 and 30. Results: Plant extract significantly (p<0.01) reduced the blood glucose levels at both the tested dose levels of 250 and 500 mg/kg. The lipid profile was estimated in which the plant extract showed significant improved in both tested dose level that is 250 and 500 mg/kg. The body weight of the animals under study was also estimated on day 1 and 30 in which a good control was observed by the plant extract. Conclusion: Antidiabetic activity of Porana paniculata whole plant extract may be due to the presence of various phytoconstituents. Present study gives a scientific evidence for the folklore claim of the plant under study for its use in diabetes.

10aDiabetes10aFolklore10alipid profile10aPorana paniculata10aStreptozotocin uhttps://phcogj.com/article/838