02306nas a2200241 4500008004100000245008300041210006900124260001300193300001200206490000700218520156100225653002801786653002001814653003901834100001801873700001501891700002801906700002201934700001901956700002801975700002602003856003502029 2019 eng d00aEvaluation of Anti-psoriatic Potential of the Fruit Rind of Punica granatum L.0 aEvaluation of Antipsoriatic Potential of the Fruit Rind of Punic cMay 2019 a466-4680 v113 a

Background: Pomegranate (Punica granatum L.) is universally known for its therapeutic properties due to its potential bioactive compounds. However, there is no established scientific study on antipsoriatic activity of pomegranate fruit rind. The aim of the study is to evaluate the anti-psoriatic activity of the isolated compounds and the extract from the fruit rind of P. granatum. In our previous study, the isolated compounds were evaluated for antioxidant potential. In continuation to the previous investigation, the present study is taken up to evaluate the extract and compounds for in vitro anti-psoriatic activity. Methods: Chromatographic techniques were employed to isolate the compounds from the aqueous acetone extract and in vitro anti-psoriatic activity was determined by thymidine phosphorylase inhibition assay. Results: From previous phytochemical investigation, three compounds were identified as Punicalagin, 2,3(S)-hexahydroxydiphenoyl-D-glucose and Punicalin. In the present study, the extract and the compounds were evaluated for anti-psoriatic activity. The results reveal that the isolated three compounds showed inhibitory activity of 89% to 95% against thymidine phosphorylase. Aqueous acetone extract also exhibited 87% inhibition. Conclusion: Punica granatum is an ideal plant for further investigation to prove its anti-psoriatic activity.

 

10aAnti-psoriatic activity10aPunica granatum10aThymidine phosphorylase inhibition1 aJacob, Janani1 aR, Gopalan1 aP, Lakshmanaperumalsamy1 aIlluri, Ramanaiah1 aBhosle, Damaji1 aSangli, Gopala, Krishna1 aMundkinajeddu, Deepak uhttps://phcogj.com/article/857