02379nas a2200241 4500008004100000245004700041210004700088260001300135300001200148490000700160520172800167653001901895653001901914653002201933653002501955653002101980100001802001700002302019700002002042700002202062700001802084856003502102 2019 eng d00aAntiulcer Property of Mussaenda philippica0 aAntiulcer Property of Mussaenda philippica cMay 2019 a603-6070 v113 a

Introduction: Mussaenda philippica (Rubiaceae) is a shrub distributed in all the planes of India, Philippines and South-East Asia. Its synonyms are M. grandiflora, M. acutifolia, M. frondosa etc. The plant is preferred as medication for the treatment of jaundice, dysentery, stomachache and influenza. The current study was based on the evaluation of antiulcer property of M. philippica leaves extract. Methods: The methods used were pylorus ligated, ethanol induced and 0.2(M) NaOH induced ulcer in rats. Results: In pylorus ligation model, aqueous extract (200 mg/kg) produced a substantial reduction in ulcer index followed by decrease in gastric volume, total acidity associated with a raise in pH, which, confirmed that tested extract of the plant act by altering the mucosal barrier Thus, the gastro protective effect of this extract may be due to the presence of flavonoid in the plant. In the same way, aqueous extract of the plant showed significant effect against ethanol induced gastric ulcer in rat as compared to methanol-treated group, which, may be due to leukotriene antagonistic effect or the inhibition of 5-lipooxygenase pathway. In NaOH induced ulcer model, aqueous extract of M. philippica revealed significant antiulcer effects on the basis of pH effect and ulcer index in rats. The anti-ulcerogenic and anti-secretory effect of the tested M. philippica leaves extracts point out its possible cyto-protective effect. Conclusion: In conclusion the aqueous extract of M. philippica leaves possess potential antiulcer activity in experimental rat models.

10aAnti-secretory10aGastric volume10aMethanol extracts10aMussaenda philippica10aPylorus ligation1 aJena, Rasmita1 aKar, Durga, Madhab1 aRath, Diptirani1 aRoy, Kaushik, Sur1 aGhosh, Goutam uhttps://phcogj.com/article/859