01921nas a2200229 4500008004100000245007100041210006900112260001800181300001200199490000700211520124600218653001901464653001801483653001301501653002301514653002201537653001801559100002301577700002801600700002801628856003501656 2019 eng d00aAntithrombotic Effect of Mucuna pruriens L. and Coriandrum sativum0 aAntithrombotic Effect of Mucuna pruriens L and Coriandrum sativu cFebruary 2019 a413-4170 v113 a

Background: Mucuna pruriens (MP) L. and Coriandrum sativum (CS) have been found for in vitro antithrombotic activity. However, the in vivo studies for both plants have not been discovered yet. Objective: The objective of the study is to prove the efficacy of MP L. and CS by conducting in vivo antithrombotic activity test with bleeding time and survival rate as the parameters. Materials and Methods: MP and CS extracts with three different doses were given orally to the experimental animals for 7 days. Aspirin was used as a positive control. The bleeding time was observed on mice tail that had been cut, and the survival rate was determined by inducing thrombosis with collagen–epinephrine injection. Results: Seven-day treatment of plant extracts significantly prolonged the bleeding time of the treated group compared to the normal control group. The result demonstrated the increasing number of survived animals in the treated group compared to the negative control group. Conclusion: Both extracts had shown antithrombotic activity by significantly prolonged the bleeding time and increased the survival rate.

10aAntithrombotic10aBleeding time10acollagen10aCoriandrum sativum10aMucuna pruriens L10aSurvival rate1 aAzmi, Nuriza, Ulul1 aNityasa, Astari, Rachma1 aSaputri, Fadlina, Chany uhttps://phcogj.com/article/861