02179nas a2200241 4500008004100000245009600041210006900137260001300206300001200219490000700231520142900238653002401667653000601691653003301697653001401730653001501744653003001759653004001789100002601829700002301855700002401878856003501902 2019 eng d00aSecondary Metabolites from Pterocaulon alopecuroides and their Antiproliferative Activities0 aSecondary Metabolites from Pterocaulon alopecuroides and their A cMay 2019 a493-4950 v113 a

Objective: To isolate secondary metabolites from the aerial parts of Pterocaulon alopecuroides, elucidate their structures and evaluate their antiproliferative activities on selected human cancer cell lines. Materials and Methods: The ethanolic extract of P. alopecuroides afforded five compounds, which were characterized using spectroscopic techniques and by comparison with data from the literature. Antiproliferative activities of all isolates were evaluated. Results: The compounds 7-(2,3-dihydroxy-3-methylbutoxy)-6-methoxycoumarin (1), 5,6-methylenedioxy- 7-(2,3-dihydroxy-3-methylbutoxy) coumarin (2), Dihydrokaempferol (3), 5,7,4´-trihydroxy- 6-(α,α-dimethylallyl)dihydroflavonol (4) and 5,4´-dihydroxy-7-(γ,γ-dimethylallyloxy)dihydroflavonol (5) were isolated. The antiproliferative activity of all compounds was evaluated in a panel of six human solid tumor cell lines showing GI50 values for the most active compounds in the low micromolar range. Conclusion: Compound 2 is reported for first time from P. alopecuroides. Isolated coumarins show no antiproliferative activity, whilst among flavonoids compound 5 showed the best antiproliferative activity.

10a4´-dihydroxy-7-(γ10a510aAntiproliferative activities10aCoumarins10aFlavonoids10aPterocaulon alopecuroides10aγ-dimethylallyloxy)dihydroflavonol1 aCastillo, Quírico, A1 aPadrón, José, M.1 aEmiliano, Anastacio uhttps://phcogj.com/article/879