02158nas a2200217 4500008004100000245013000041210006900171260001900240300001200259490000700271520146500278653002701743653001701770653001301787653001901800653001001819100002401829700002801853700002401881856003501905 2019 eng d00aAloe Vera Peel Extract Administration Increased Antioxidant Enzyme Levels of Serum and Seminal Plasma in Type 2 Diabetic Rats0 aAloe Vera Peel Extract Administration Increased Antioxidant Enzy cSeptember 2019 a962-9670 v113 a

Background: Diabetes mellitus (DM) is considered as a complex metabolic disorder characterized by hyperglycemia. Aim: The present study aimed to evaluate the effect of Aloe vera peel extract on the antioxidant levels of serum and seminal plasma of type 2 diabetic rats. Materials and Methods: Male Wistar rat was injected by 65 mg/kg streptozotocin (STZ) combined with 230 mg/kg of Nicotinamide acid (NA) intraperitoneally. The rats were declared to have diabetic with fasting blood glucose level > 200 mg/dl 72 hours after induction. Diabetic rat samples were divided into four groups, control group (diabetes without treatment) and three groups were treated by Aloe vera peel extracts orally: 100 mg (P.1), 200 mg (P.2), and 400 mg/kg body weight (P.3), respectively. Antioxidant levels of serum and seminal plasma, including superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) were examined after 28 days of treatment. Results: The levels of SOD, CAT, and GSH in the group receiving Aloe vera peel extract were statistically significant (p <0.05) higher than the control. There were also significant differences between the dose variations group. Conclusion: Aloe vera peel extract can significantly increase antioxidant levels in serum and seminal plasma of type 2 diabetic mice.

10aAloe vera peel extract10aAntioxidants10aDiabetes10aSeminal Plasma10aSerum1 aChristijanti, Wulan1 aJuniarto, Achmad, Zulfa1 aSuromo, Lisyani, B. uhttps://phcogj.com/article/961