TY - JOUR T1 - In Silico Study of the Potential of Endemic Sumatra Wild Turmeric Rhizomes (Curcuma Sumatrana: Zingiberaceae) As Anti-Cancer JF - Pharmacognosy Journal Y1 - 2022 A1 - Aldi Tamara Rahman A1 - Rafia A1 - Aiken Jethro A1 - Putra Santoso A1 - Viol Dhea Kharisma A1 - Ahmad Affan Ali Murtadlo A1 - Devi Purnamasari A1 - Nunuk Hariani Soekamto A1 - ANM Ansori A1 - Kuswati A1 - Riso Sari Mandeli A1 - Kawther Ameen Muhammed Saeed Aledresi A1 - Nur Farhana Mohd Yusof A1 - Vikash Jakhmola A1 - Maksim Rebezov A1 - Maksim Rebezov A1 - Rahadian Zainul A1 - Kiran Dobhal A1 - Tarun Parashar A1 - Muhammad Arya Ghifari A1 - Deffi Ayu Puspito Sari KW - Anticancer KW - C. sumatrana KW - in silico AB -

Cancer is one of the diseases that is the highest cause of death in humans. Most human cancer cells are formed as a result of over-expression of anti-apoptotic proteins. Thus, the activation of these proteins can inhibit pro-apoptotic proteins, then apoptosis will be inhibited so that other apoptotic pathways need to be activated to prevent cancer cells from developing. Current cancer treatments, such as chemotherapy using synthetic compounds, have various side effects, so research on natural based therapies can be used as an alternative in cancer treatment. Curcuma sumatrana is one of the plants of the Zingiberaceae family which is an endemic plant from Sumatra which is found along the Bukit Barisan. The research was carried out in silico by analyzing the potential bioactivity of the compounds, testing the bioavailability, toxicity, and molecular docking of the bioactive compounds from the ethanol extract of the rhizome of C. sumatrana which had been previously identified through gas chromatography-mass spectroscopy (GCMS) analysis. The results obtained that the compound 9-Acetyl-S-octahydrophenanthrene and 3-Oxoandrosta- 1,4-dien-17.beta.-spiro-2'-3'-oxo-oxetanecontained in C. sumatrana has the potential to be developed as an anticancer where the compound has good bioavailability value and is not toxic and potentially can trigger apoptosis. However, the results of this study need to be analyzed further with an in vitro or in vivo approach.

VL - 14 IS - 6 ER -