TY - JOUR T1 - Correlation of the Presence of Non Structural-1 (NS1) Antigen Dengue Virus with Severity of Dengue Infection JF - Pharmacognosy Journal Y1 - 2022 A1 - Ichwan Baihaki A1 - Beti Ernawati Dewi A1 - Viol Dhea Kharisma A1 - Ahmad Affan Ali Murtadlo A1 - Muhammad Badrut Tamam A1 - Devi Purnamasari A1 - Nunuk Hariani Soekamto A1 - ANM Ansori A1 - Kuswati A1 - Riso Sari Mandeli A1 - Kawther Ameen Muhammed Saeed Aledresi A1 - Nur Farhana Mohd Yusof A1 - Vikash Jakhmola A1 - Maksim Rebezov A1 - Pavel Burkov A1 - Marina Derkho A1 - Pavel Scherbakov A1 - Rahadian Zainul A1 - Muhammad Raffi Ghifari A1 - Asmi Citra Malina AR Tasakka A1 - Tengku Siti Hajar Haryuna KW - Dengue virus KW - NS1 antigen KW - Thrombocytopenia AB -

Dengue is a major public health threat worldwide, affecting approximately 3 billion people. More than 100 countries in the world located in tropical and subtropical areas, there are at least 100 to 400 million people infected with the dengue virus which causes dengue hemorrhagic fever (DHF). Soluble Non Structural Protein (sNS1) DENV is a soluble NS1 protein that is secreted and found in the serum of patients during acute infection. Because of its presence early in infection, sNS1 is used as a diagnostic indicator of acute dengue infection. NS1 can directly activate platelets through TLR4 and can further increase platelet aggregation, endothelial cell adhesion, and phagocytosis by macrophages that can cause thrombocytopenia so that high sNS1 levels are associated with disease severity. From the results of the study showed p <0.05. This indicates that there is a correlation between the presence of NS1 and the severity of dengue infection.

VL - 14 IS - 6 ER -