TY - JOUR T1 - Differences in interleukin-6 and interleukin-17 expression in covid-19 post-mortem lung tissue biopsy compared with noncovid- 19 JF - Pharmacognosy Journal Y1 - 2022 A1 - Etty Hary Kusumastuti A1 - Priangga Adi Wiratama A1 - Grace Ariani A1 - Stephanie Natasha Djuanda A1 - Alphania Rahniayu A1 - Nila Kurniasari A1 - Dyah Fauziah A1 - Anny Setijo Rahaju A1 - Isnin Anang Marhana A1 - Alfian Nur Rosyid A1 - Dwi Wahyu A1 - Gilang Muhammad Setyo Nugroho A1 - Adhitri Anggoro A1 - I Komang Rusgi Yandi A1 - Bambang Pujo Semedi A1 - Jilientasia Godrace Lilihata A1 - Ummi Maimunah A1 - Supriadi A1 - Achmad Lefi A1 - Lalu Galih Pratama Rinjani A1 - Edi Suyanto A1 - Ricardo Ardian Nugraha KW - Biopsy KW - COVID-19 KW - IL-17 KW - IL-6 KW - Post mortem lung tissue. AB -

Background: COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality. Objective: This study aims to determine the differences in the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients compared to non-COVID-19 patients. This study also aimed to analyze the correlation between the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients. Methods: This research is an observational analytic study with crosssectional approach. The samples were 15 paraffin blocks of post-mortem lung tissue biopsy of COVID-19 patients, and 15 paraffin blocks of inflammatory lung tissue biopsy or surgery of non-COVID-19 patients. IL-6 and IL-17 expressions were evaluated by immunohistochemical procedure. Result: There was a significant difference in the expression of IL-6 in the COVID-19 group and the non-COVID-19 group with a p-value = 0.001 (p < 0.05). There was a significant difference in the expression of IL-17 in the COVID-19 group and the non-COVID-19 group with p-value = 0.001 (p < 0.05). There was a significant correlation between the expressions of IL-6 and IL-17 in the COVID-19 group, with the Spearman coefficient value (rs) of 0.548 with p = 0.034 (p < 0.05). Conclusion: There are differences in the expression of IL-6 and IL-17 between COVID-19 and non-COVID-19 lung tissue. There is a significant correlation between the expressions of IL-6 and IL-17 in post-mortem lung tissue of COVID-19 patients.

VL - 14 IS - 6s ER -