<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author><author><style face="normal" font="default" size="100%">Linder Figueroa-Salvador</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effect of Sacha Inchi Oil (Plukenetia volubilis L.) in an Experimental Model of Epilepsy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Convulsion</style></keyword><keyword><style  face="normal" font="default" size="100%">Epilepsy</style></keyword><keyword><style  face="normal" font="default" size="100%">Omega</style></keyword><keyword><style  face="normal" font="default" size="100%">Pentylenetetrazole</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha inchi</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1591-1596</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Experimental studies have demonstrated that fatty acids such as omega 3 and 6 have anti-inflammatory, anticonvulsant, cardio protective and anti-tumor effects. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective was to determine the protective effect of sacha inchi oil on pentylenetetrazoleinduced seizures in albino mice. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Thirty male Balb/C albino mice of 8 weeks of age were purchased from the National Institute of Health (Lima-Peru). The animals were divided into 5 groups of 6 animals each one. Group I: Control; PTZ (pentylenetetrazole 80 mg / kg, s.c.). II: PTZ + Diazepam (1 mg / kg; s.c.). Group III, IV, V: PTZ + sacha inchi oil at single doses of 250, 500, 1000 mg / kg respectively orally. Sacha inchi oil was administered 30 minutes before induction of seizures by PTZ. Next, various parameters such as latency, seizure frequency, duration and score were scored according to Racine scale. The program Graph Pad Prism v.4 was used for statistical analysis. &lt;strong&gt;Results: &lt;/strong&gt;As result, the experimental group treated with sacha inchi oil at maximum dose of 1000 mg/kg showed better results in response to PTZ induced seizure; low levels of seizures, frequency and duration (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.001; ANOVA, &lt;em&gt;P&lt;/em&gt; &amp;lt;0.001 Post-hoc Dunnett test). &lt;strong&gt;Conclusion: &lt;/strong&gt;It is concluded that Sacha inchi oil presented anticonvulsant effect at the highest doses tested being very similar to Diazepam. The main mechanism could be by reducing free radical and improving GABA levels in the brain.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;2&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;3&lt;/sup&gt;, César Franco- Quino&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz- Cerrate&lt;sup&gt;5&lt;/sup&gt;, Linder Figueroa- Salvador&lt;sup&gt;6 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica Del Sur, Lima, PERU. 6School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Medicine, Universidad Peruana de&amp;nbsp;Ciencias Aplicadas, Lima PERU.&lt;/p&gt;
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