<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Agriana Rosmalina Hidayati</style></author><author><style face="normal" font="default" size="100%">Aty Widyawaruyanti</style></author><author><style face="normal" font="default" size="100%">Hilkatul Ilmi</style></author><author><style face="normal" font="default" size="100%">Mulyadi Tanjung</style></author><author><style face="normal" font="default" size="100%">Tri Widiandani</style></author><author><style face="normal" font="default" size="100%">Siswandono</style></author><author><style face="normal" font="default" size="100%">Din Syafruddin</style></author><author><style face="normal" font="default" size="100%">Achmad Fuad Hafid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimalarial Activity of Flavonoid Compound Isolated from Leaves of Artocarpus altilis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Artocarpus altilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cysteine protease inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Dihydrochalcones</style></keyword><keyword><style  face="normal" font="default" size="100%">P. falciparum 3D7</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">835-842</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Artocarpus altilis&lt;/em&gt; leaves extract has previously been reported as a potential antimalarial drug. Inhibition concentration (IC&lt;sub&gt;50&lt;/sub&gt;) against &lt;em&gt;P. falciparum&lt;/em&gt; and effective dose values (ED&lt;sub&gt;50&lt;/sub&gt;) against P. berghei have been reported at 1.32 μg/ml and 0.82 mg/kg, respectively. The aim of this study is to identify the active compound from the ethanol extract of &lt;em&gt;A. Altilis&lt;/em&gt; leaves against &lt;em&gt;P. falciparum.&lt;/em&gt; Materials and Methods: The isolation of the active compound from the ethanol extract of&lt;em&gt; A. altilis &lt;/em&gt;were conducted using chromatography methods, and the chemical structure of the isolated compounds was determined based on NMR and MS spectra data. Antimalarial assay was determined using microscopic method against &lt;em&gt;P. falciparum&lt;/em&gt; 3D7 and molecular docking studies was performed using Molegro Virtual Docker version 5.5 program. &lt;strong&gt;Results:&lt;/strong&gt; A flavonoid compound, class of dihydrochalcone was finally isolated from &lt;em&gt;A. altilis &lt;/em&gt;and identified as&lt;em&gt; 1-(2,4-dihydroxy phenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3- pentenyl)-2H-1-benzopyran-5-yl]-1-propanone&lt;/em&gt; (Compound-1). Antimalarial activity test revealed that the compound strongly inhibited &lt;em&gt;P. falciparum&lt;/em&gt; growth, with IC&lt;sub&gt;50&lt;/sub&gt; value of 1.05 μM. An in silico study to determine the mechanism of action of the compound revealed the existence a 3.BPF receptor that possesses a cysteine protease inhibitor of falcipain-2. &lt;strong&gt;Conclusion: &lt;/strong&gt;Compound-1 were isolated from the leaves of &lt;em&gt;A. Altilis&lt;/em&gt; is a good candidate of new source in the development of antimalarial drugs. An animal study using this compound is recommended before a clinical trial.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">835</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Agriana Rosmalina Hidayati&lt;sup&gt;1,2&lt;/sup&gt;, Aty Widyawaruyanti&lt;sup&gt;3,4,&lt;/sup&gt;*, Hilkatul Ilmi&lt;sup&gt;4&lt;/sup&gt;, Mulyadi Tanjung&lt;sup&gt;4,5&lt;/sup&gt;, Tri Widiandani&lt;sup&gt;6&lt;/sup&gt;, Siswandono&lt;sup&gt;6&lt;/sup&gt;, Din Syafruddin&lt;sup&gt;7,8&lt;/sup&gt;, Achmad Fuad Hafid&lt;sup&gt;3,4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Post Graduate Student of Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Universitas Mataram, Mataram 83125, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60826, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Departement of Pharmaceutical Chemistry Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Eijkman Institute for Molecular Biology, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar 90245, INDONESIA.&lt;/p&gt;
</style></auth-address></record></records></xml>