<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ade Heri Mulyati</style></author><author><style face="normal" font="default" size="100%">Ahmad Sulaeman</style></author><author><style face="normal" font="default" size="100%">Sri Anna Marliyati</style></author><author><style face="normal" font="default" size="100%">Mohamad Rafi</style></author><author><style face="normal" font="default" size="100%">Al Mukhlas Fikri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preclinical Trial of Propolis Extract in Prevention of High Salt Diet- Induced Hypertension</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antihypertension</style></keyword><keyword><style  face="normal" font="default" size="100%">Blood pressure</style></keyword><keyword><style  face="normal" font="default" size="100%">High-NaCl diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Stingless bee propolis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">89-96</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Propolis has been widely reported as having various biological activities. However, Indonesian propolis seems to be less explored. &lt;strong&gt;Objective:&lt;/strong&gt; The present study aimed to analyze the antihypertensive activity of Indonesian propolis in rats.&lt;strong&gt; Materials and Methods: &lt;/strong&gt;Hypertension was induced by high-NaCl (8%) diet for 3 weeks. A total of 36 rats were divided into 6 groups, including standard diet group (SD), high-NaCl diet group (NaD), high-NaCl diet group + captopril (25 mg/ kg) (PD), high-NaCl diet + propolis from Riau Archipelago (NaDP1), high-NaCl diet + propolis from Lampung (NaDP2) and high-NaCl diet + propolis from South Sulawesi (NaDP3). Propolis was daily administered at dose of 200 mg/ kg on hypertensive rats for 1 week. Blood pressure and body weight were weekly measured. Moreover, routine urine analysis, haematological parameters and lipid profiles at week 4 were determined.&lt;strong&gt; Results:&lt;/strong&gt; The results showed that high-NaCl diet successfully induced hypertension in rats after 3 weeks of intervention. However, the diet did not cause weight gain (p&amp;gt;0.05). All Indonesian propolis samples significantly reversed either systolic or diastolic blood pressure of hypertensive rats. From urine analysis, propolis from Riau Archipelago and Lampung showed diuretic effect. The haematological analysis mainly showed no significant difference compared standard diet group. Furthermore, LDL and HDL concentrations were significantly improved by propolis from Lampung and South Sulawesi, respectively (p&amp;lt;0.05). In addition, we only found significant decrease in relative weight of liver in all groups administered with high-NaCl diet (p&amp;lt;0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;The present study suggests that all Indonesian propolis possessed antihypertensive activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">89</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ade Heri Mulyati&lt;sup&gt;1,2&lt;/sup&gt;, Ahmad Sulaeman&lt;sup&gt;1,&lt;/sup&gt;*, Sri Anna Marliyati&lt;sup&gt;1&lt;/sup&gt;, Mohamad Rafi&lt;sup&gt;3&lt;/sup&gt;, Al Mukhlas Fikri&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor 16680, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Pakuan, Bogor 16163, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, INDONESIA&lt;/p&gt;
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