<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Deepa Shukla</style></author><author><style face="normal" font="default" size="100%">Sajal Srivastava</style></author><author><style face="normal" font="default" size="100%">Talha Jawaid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Learning and Memory Enhancing Activity of Polyherbal Formulation on Streptozotocin Induced Memory Impairment in Rats via Reducing Mitochondria–Targeted Cytochrome</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alpinia galanga</style></keyword><keyword><style  face="normal" font="default" size="100%">Convolvulus pluricaulis</style></keyword><keyword><style  face="normal" font="default" size="100%">Elevated Plus Maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycerrhiza glabra</style></keyword><keyword><style  face="normal" font="default" size="100%">Pole climbing test</style></keyword><keyword><style  face="normal" font="default" size="100%">Social recognition test</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">230-240</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Neurodegenerative diseases and/or brain injury may occur due to mild to severe memory disorders in which Alzheimer's disease (AD) is defined as degradation of neurons and there is no effective therapy or cure for the disease. The intention behind this study was to determine memory enhancing effect of an Ayurvedic polyherbal formulation (PHF) in Streptozotocin-induced memory deficit experimental animal models. &lt;strong&gt;Methods:&lt;/strong&gt; Polyherbal formulation (PHF) was a suspension of three plant extracts i.e. &lt;em&gt;Alpinia galanga, Glycerrhiza glabra &lt;/em&gt;and&lt;em&gt; Convolvulus pluricaulis&lt;/em&gt; along with other excipients. Different behavioral animal models like Social recognition test (SRT), Morris water maze (MWM) test, Pole climbing test (PCT) and Elevated plus maze (EPM) test were used to evaluate efficacy of Polyherbal formulation (PHF) in learning and memory process of animals. Gene expression was performed by RT-PCR and western blot. &lt;strong&gt;Results:&lt;/strong&gt; Results indicated that time of social recognition during trial 2 (SIT2) was reduced significantly (P&amp;lt;0.01) due to PHF administration. In MWM test, treatment with PHF significantly (P&amp;lt;0.01) reduced [F (4, 20) = 6.9] latency to reach hidden platform from session 3. Similarly, PHF was also found effective in pole climbing test and EPM test. RT-PCR results showed p53 regulates the Bcl-2 family proteins its expression in the given experiment was appreciably reduced in PHF (200mg/kg). NR1, NR2B and GAP-43 proteins leads to reduction of brain cell damage. &lt;strong&gt;Conclusion: &lt;/strong&gt;Thus, PHF may be an effective formulation for learning and memory process against STZ-induced memory impairment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">230</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Deepa Shukla&lt;sup&gt;1,2&lt;/sup&gt;, Sajal Srivastava&lt;sup&gt;2,&lt;/sup&gt;*, Talha Jawaid&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmacy, Sharda University, Greater Noida, Uttar Pradesh, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, Lucknow 226010, Uttar Pradesh, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, College of Medicine, Al Imam Mohammad Ibn Saud Islamic University, P.O. Box 11623, Riyadh 11544, SAUDI ARABIA.&lt;/p&gt;
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