<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afriwardi</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Yolanda Alfiyyah Larakhansa</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunostimulatory Activities of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) in White Male Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hydrocotyle sibthorpioides Lam.</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Macrophage</style></keyword><keyword><style  face="normal" font="default" size="100%">Phagocytosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus aureus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">368-375</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Pegagan embun&lt;/em&gt; (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) has many pharmacological activies, such as improving the immune system. &lt;strong&gt;Aim: &lt;/strong&gt;This research aims to study the immunomodulatory effect of &lt;em&gt;Pegagan embun&lt;/em&gt; herbs ethanol extract (&lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;L.) determined by phagocytic activity and capacity of macrophages, total and percentage of leukocytes. &lt;strong&gt;Methods: &lt;/strong&gt;25 male white mice were divided into 5 equal groups. Negative control group were given Na CMC 0.5%, the extract treated group were given &lt;em&gt;Pegagan embun&lt;/em&gt; ethanol extract at doses of 10, 50, 200 mg/kgbw, and the positive control group was given Stimuno 50 mg/kgbw orally for 7 days. On the 8&lt;sup&gt;th&lt;/sup&gt; day, the total and percentage of leukocytes were counted through blood sample taken intravenously. The mice were then induced with &lt;em&gt;Staphylococcus aureus &lt;/em&gt;suspension. After one hour, the peritoneal fluids was taken to determine the macrophages activity and capacity. The macrophages phagocytic activity and capacity, total and percentage of leukocytes were analyzed by One-Way Anova followed by Duncan Multiple Range Test (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Results:&lt;/strong&gt; The results show significant increase of concentration (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05) towards macrophages phagocytic activity and capacity, and total leukocytes count. Percentage of leukocytes show that lymphocytes increase significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05), meanwhile neutrophils segments decrease significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;It can be concluded that ethanol extract of &lt;em&gt;Pegagan embun&lt;/em&gt; herb at doses of 10, 50, 200 mg/kgbw shows immunostimulatory activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">368</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Afriwardi&lt;sup&gt;1,&lt;/sup&gt;*, Yufri Aldi&lt;sup&gt;2&lt;/sup&gt;, Dwisari Dillasamola&lt;sup&gt;2&lt;/sup&gt;, Yolanda Alfiyyah Larakhansa&lt;sup&gt;2&lt;/sup&gt;, Elsa Badriyya&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Andalas University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record></records></xml>