<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siordia-Reyes Georgina A</style></author><author><style face="normal" font="default" size="100%">Cornejo-Garrido Jorge</style></author><author><style face="normal" font="default" size="100%">Jiménez-Arellanes M. Adelina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nephro- and hepatoprotective effect of Rosmarinus officinalis against damage induced with antiTB drugs using a chronic model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antitubercular drug</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotection</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephroprotective effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Rosmarinus officinalis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">722-729</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Nephro- and hepatoprotector effect of MeOH extract from &lt;em&gt;R. officinalis&lt;/em&gt; against the liver and kidney damage caused by the mixture of RIF:INH:PZA, using a chronic&lt;em&gt; in vivo&lt;/em&gt; model are described. MeOH extract (EMRO) was prepared by maceration process and was administered by oral via during 91 days in male Balb/C mice with RIF:INH:PZA-induced renal/liver damage, using silymarin (SIL) as a positive control. EMRO (250 mg/kg) favoured body weight gain respect to the antiTB group, this gain was better than that shown by the SIL. The AST and ALT values of the group that received the EMRO extract and SIL were similar to that the control group and low compared to the group antiTB with liver damage. In addition, the GPx, CAT and POx values of the group treated with the EMRO were similar to that the control group. In the liver histological analysis, no significant alteration was observed; however, a severe nephritis was observed in anti-TB group (II) and this effect was less in groups III (antiTB/SIL) and IV (antiTB/EMRO). MeOH extract enhances body weight gain and primarily protects the kidney and liver from damage caused by the antiTB drug mixture when was administered for 91 days.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">722</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siordia-Reyes Georgina A&lt;sup&gt;1&lt;/sup&gt;, Cornejo-Garrido Jorge&lt;sup&gt;2&lt;/sup&gt;, Jiménez- Arellanes M. Adelina&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departamento de Patología, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN-SXXI), Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtémoc 330, Col. Doctores, 06720, Ciudad de México (CDMX), MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratorio de Biología Celular y Productos Naturales, Escuela Nacional de Medicina y Homeopatía (ENMH), Instituto Politécnico Nacional, Guillermo Massieu Helguera 239, Col. La Escalera, Del. Gustavo A. Madero, 07320 CDMX, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Unidad de Investigación Médica (UIM) en Farmacología, UMAE Hospital de Especialidades, CORSE 2º piso, CMN-SXXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, 06729, CDMX, MEXICO.&lt;/p&gt;
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