<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lakshmi.T</style></author><author><style face="normal" font="default" size="100%">Rajendran.R</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Acetyl cholinesterase inhibitory assay of Acacia catechu Willd ethanolic seed extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acacia catechu seed</style></keyword><keyword><style  face="normal" font="default" size="100%">Acetyl cholinesterase inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Alzheimer’s disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Spectrophotometric analysis.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">9th June 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">1-1</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim &amp;amp; objective:&lt;/strong&gt; The aim of this study was to evaluate acetyl cholinesterase inhibitory activity of &lt;em&gt;Acacia catechu&lt;/em&gt; ethanolic seed extract to introduce a new source for management of Alzheimer&amp;rsquo;s disease. &lt;strong&gt;Background&lt;/strong&gt;: Alzheimer&amp;rsquo;s disease is a complex, multifactorial, progressive, neurodegenerative disease primarily affecting the elderly population and is estimated to account for 50&amp;ndash;60% of dementia cases in persons over 65 years of age. It is likely that the inhibition of acetyl cholinesterase by&lt;em&gt; Acacia catechu&lt;/em&gt; ethanolic seed extract that is rich in flavonoids and antioxidants may aid in the protection of neurodegenerative disorders and ultimately Alzheimer&amp;#39;s disease. &lt;strong&gt;Methods:&lt;/strong&gt; Anti cholinesterase activity is determined by adopting &lt;em&gt;In vitro&lt;/em&gt; standard protocol. &lt;strong&gt;Results:&lt;/strong&gt; According to the obtained results, the inhibitory activity (IC&lt;sub&gt;50&lt;/sub&gt; values, &amp;mu;g /ml) of extracts was 204.38 &amp;plusmn; 2.54 &amp;micro; g/ml. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results indicated and confirmed the traditional use of &lt;em&gt;Acacia catechu&lt;/em&gt; ethanolic seed extract for management of central nervous system disorders. It showed the moderate activity in inhibition of acetyl cholinesterase at various concentrations. However, further investigations on identification of active components in the extracts are needed.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words&lt;/strong&gt;: &lt;em&gt;Acacia catechu&lt;/em&gt; seed, Acetyl cholinesterase inhibitor, Alzheimer&amp;rsquo;s disease, spectrophotometric analysis.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Lakshmi. T &lt;sup&gt;*1&lt;/sup&gt;, Rajendran. R &lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Assistant professor ,Department of Pharmacology ,Saveetha Dental College &amp;amp; Hospitals, Chennai, India.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Green Chem Herbal Extracts &amp;amp; Formulations,Bangalore,India.&lt;/p&gt;</style></auth-address></record></records></xml>