<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Noor Kamil</style></author><author><style face="normal" font="default" size="100%">Hafi z Syed Imran-ul-Haque</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Calotropis procera</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">isoniazid</style></keyword><keyword><style  face="normal" font="default" size="100%">rifampicin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2nd July 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">9-14</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; In this study anti-tubercular drugs (isoniazid and rifampicin) induced liver toxicity has been studied for the hepatoprotective effect of hydroethanolic extract of &lt;em&gt;Calotropis procera&lt;/em&gt; (CP) flowers in rats. &lt;strong&gt;Materials and Method:&lt;/strong&gt; Animals were divided into four groups, group Awas given normal saline (1ml/kg), group B received Isoniazid (INH) (50mg/kg) and Rifampicin (RMP)(100mg/kg) group C received INH (50mg/kg), RMP(100mg/kg) and CP(150mg/kg)orally for fourteen days. &lt;strong&gt;Results:&lt;/strong&gt; Biochemical markers of liver toxicity such as AST,ALT,ALP, bilirubin and tissue histology were done inall groups. Anti-Tubercular (Anti-TB) drugs (INH 50mg/kg and RMP100mg/kg) have enhanced the ALT, AST, ALP, bilirubin and histological changes in liver, whereas co-administration of anti-TB drugs with Calotropis procera has reduced these levels within the normal range. &lt;strong&gt;Conclusion:&lt;/strong&gt; Findings of this study showed the hepatoprotective effct of Calotropis Proceraagainst Isoniazid and Rifampicinadministration to reduce the liver damage for chronic treatment.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Isoniazid, Rifampicin, &lt;em&gt;Calotropis procera&lt;/em&gt;, Hepatoprotective.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Noor Kamil&lt;sup&gt;1&lt;/sup&gt;, Hafiz Syed Imran-ul-Haque&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;2 &lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982-KSA,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Dow International Medical College, Dow University of Health Sciences, Karachi-Pakistan.&lt;/p&gt;</style></auth-address></record></records></xml>