<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sireesha Pulla</style></author><author><style face="normal" font="default" size="100%">Nagarjuna Sannithi</style></author><author><style face="normal" font="default" size="100%">Siva Reddy Challa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunomodulatory Effect of Water Soluble Polysaccharides Isolated from Metroxylon sagu in Animal Models of Immunosuppression</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Immunomodulation</style></keyword><keyword><style  face="normal" font="default" size="100%">immunosuppression</style></keyword><keyword><style  face="normal" font="default" size="100%">Metroxylon sagu</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Polysaccharides</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2nd July 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">55-62</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; This study was aimed to investigate the immunomodulatory activity of water soluble polysaccharides isolated from &lt;em&gt;Metroxylon sagu&lt;/em&gt; (PSMS) by dilute acid extraction, ethanol precipitation in rats by using three different &lt;em&gt;in-vivo&lt;/em&gt; experimental models of immunosuppression. &lt;strong&gt;Methodology: &lt;/strong&gt;Three models of immunosuppression include metronidazole (MTZ) induced immunosuppression, pyrogallol induced immunosuppression and Ethanol-induced immunosuppression. Immunological indices like humoral antibody titer values, cellular immune response, percent change in phagocytosis, serum immunoglobulins were estimated. Histopathology of spleen was done in all control and treated groups. The doses of 500 and 250 mg/kg of PSMS were administered orally to evaluate the immunomodulatory activity. &lt;strong&gt;Results:&lt;/strong&gt; Though PSMS was demonstrated to have immunostimulatory activity in almost all three models of immunosuppression, PSMS was found to be more effi cacious against ethanol-induced immunosuppression when compared with pyrogallol induced immunosuppression and MTZ induced immunosuppression. However, dose-dependent improvement in immunological indices was evident in all three models. &lt;strong&gt;Conclusion:&lt;/strong&gt; In summary, water soluble polysaccharides isolated from &lt;em&gt;M. sagu&lt;/em&gt; stimulate the immunity in the animal models of immunosuppression.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Immunomodulation, immunosuppression, &lt;em&gt;Metroxylon sagu&lt;/em&gt;, oxidative stress, polysaccharides.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sireesha Pulla&lt;sup&gt;1&lt;/sup&gt;, Nagarjuna Sannithi&lt;sup&gt;1&lt;/sup&gt;, Siva Reddy Challa&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;2*&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research, Ananthapur, Andhra Pradesh, India,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.&lt;/p&gt;</style></auth-address></record></records></xml>