<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Asmaa Sayed Abd Elkarim</style></author><author><style face="normal" font="default" size="100%">Amal H. Ahmed</style></author><author><style face="normal" font="default" size="100%">Abdelbaset M. Elgamal</style></author><author><style face="normal" font="default" size="100%">Radwan El Haggar</style></author><author><style face="normal" font="default" size="100%">Alaa Khedr</style></author><author><style face="normal" font="default" size="100%">Mohamed Fouad Shalaby</style></author><author><style face="normal" font="default" size="100%">Roula Bayram</style></author><author><style face="normal" font="default" size="100%">Samah Shabana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evidence Based Evaluation of Pharmacological Activity and Herb-Herb interaction of Organic Extracts of Certain Natural Anti- Diabetic Mixtures</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-diabetic herbs</style></keyword><keyword><style  face="normal" font="default" size="100%">Herb-herb interaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal Plants.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1366-1376</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This work aims to find a new treatment based on the development of safe natural anti-diabetic mixtures. It assesses the hypoglycemic activity of natural mixtures and determines whether there are any negative side effects from the interaction of the herbs and the herbs. &lt;strong&gt;Methods:&lt;/strong&gt; Six natural mixtures were tested for anti-diabetic activity, which was confirmed by a pathological histological examination. We performed a GC-MS analysis on active mixtures 1 and 2, yielding 54 and 38 compounds, respectively. The major compounds were Gingerol, Butan-2-one and 4-(3-hydroxy-2-methoxyphenyl) (97 and 64.02 per cent). &lt;strong&gt;Results: &lt;/strong&gt;Among the six samples, the organic extract of mixture 1 and 2 showed a significant reduction in BGL compared to the standard drug glimepiride at a dose of 10 mg/kg ip and demonstrated a beneficial effect on renal function in alloxan-induced diabetic mice. These results were confirmed by a histopathological study which revealed that both mixture 1 and mixture 2 had decreased morphological and ultrastructural changes in the triggered liver. Docking of cuminaldehyde, Gingerol and α-Copaenin at the active site of human pancreatic enzymes α-amylase and aldol reductase revealed that these compounds had binding affinity at the active site of the enzymes. &lt;strong&gt;Conclusion: &lt;/strong&gt;Our results revealed the anti-diabetic activity of non-polar mixtures consisting of long chain hydrocarbons, oils and non-polar components, thus suggesting that the herbal formulation is safe and effective for the treatment and complication of type 2 diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1366</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Asmaa Sayed Abd Elkarim&lt;sup&gt;1,*&lt;/sup&gt;, Amal H. Ahmed&lt;sup&gt;2,&lt;/sup&gt; Abdelbaset M. Elgamal&lt;sup&gt;3&lt;/sup&gt;, Radwan El Haggar&lt;sup&gt;4&lt;/sup&gt;, Alaa Khedr&lt;sup&gt;5&lt;/sup&gt;, Mohamed Fouad Shalaby&lt;sup&gt;5&lt;/sup&gt;, Roula Bayram&lt;sup&gt;5&lt;/sup&gt;, Samah Shabana&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Chemistry of Tanning Materials and Leather Technology Department, National Research Centre, 33 El Bohouthst. (former EL Tahrirst.)- Dokki-Giza, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy Department, Faculty of Pharmacy, Al-azhar University, 11884 Nasr City, Cairo, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Chemistry of Natural and Microbial Products Department, National Research Centre, 33 El Bohouth st. (former EL Tahrir st.)-Dokki- Giza-EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo 11795, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of pharmacognosy, Faculty of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, MUST, 6th October City, EGYPT.&lt;/p&gt;
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