<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kumboyono Kumboyono</style></author><author><style face="normal" font="default" size="100%">Indah Nur Chomsy</style></author><author><style face="normal" font="default" size="100%">Fitria Nugraha Aini</style></author><author><style face="normal" font="default" size="100%">Titin Andri Wihastuti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correlation Pattern of oxLDL, cortisol, hsCRP, and Adiponectin Levels in Atherosclerosis Risk Population-Based on Framingham Risk Score</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">14-20</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The central pathology of cardiovascular disease (CVD) is atherosclerosis. Therefore, it is necessary to examine proteins involved in the and CVD disease mechanism to predict the occurrence of cardiovascular disease due to atherosclerosis. &lt;strong&gt;Purpose: &lt;/strong&gt;This study analysed the correlation pattern of hsCRP, oxLDL, cortisol, and adiponectin levels in atherosclerotic risk population based on the Framingham Risk Score (FRS) to determine the risk of atherosclerosis. &lt;strong&gt;Methods&lt;/strong&gt; Participants were selected using the purposive sampling method,158 participants classes were fired into three risk groups according to FRS. Blood samples were collected, a hsCRP, oxLDL, cortisol, and adiponectin levels were measured using Enzyme-linked Immunosorbent Assay (ELISA). &lt;strong&gt;Results and Discussion&lt;/strong&gt;: Using the inner model test result, four significant direct relationships are formed, indicated by p-value&amp;lt; 0.000. It was FRS to oxLDL, cortisol adiponectin, cortisol to oxLDL, and oxLDL to adiponectin. Based on the indirect effect analysis, it is known that the indirect effect of FRS on Adiponectin through the increase in hs-CRP levels (0.211), FRS on Adiponectin increases in OxLDL levels is significant (-0.224). The coefficient of the effect of the FRS on Adiponectin levels through an increase in OxLDL levels is negative, and also FRS on Adiponectin. The indirect effect of FRS on Adiponectin is that the indirect effect and is not significant (4.083) through the increase in cortisol levels. &lt;strong&gt;Conclusion&lt;/strong&gt;: All variables used in this study are correlated with each other. FRS with hsCRP and adiponectin form a relationship that directly affects each other. Meanwhile, FRS affect adiponectin through OxLDL and cortisol.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Adiponectin, Atherosclerosis, Cardiovascular disease, Framingham Risk Factor, hsCRP.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">14</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kumboyono Kumboyono&lt;sup&gt;1&lt;/sup&gt;, Indah Nur Chomsy&lt;sup&gt;2&lt;/sup&gt;, Fitria Nugraha Aini&lt;sup&gt;3&lt;/sup&gt;, Titin Andri Wihastuti&lt;sup&gt;1&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Nursing, Faculty of Medicine, University of Brawijaya, Malang, 65145, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, University of Brawijaya, Malang, 65145, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, University of Islam Malang, Malang, INDONESIA&lt;/p&gt;
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