<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lukman La Basy</style></author><author><style face="normal" font="default" size="100%">Djoko Santosa</style></author><author><style face="normal" font="default" size="100%">Retno Murwanti</style></author><author><style face="normal" font="default" size="100%">Triana Hertiani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Uncover Itchy Leaves Ethnomedicine Usage: A Preliminary Study on Characterization and Bioactivity of Laportea Spp</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Characterization</style></keyword><keyword><style  face="normal" font="default" size="100%">Cox-2 inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH radical scavenging activity.</style></keyword><keyword><style  face="normal" font="default" size="100%">Itchy leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Laportea decumana (Roxb.) Wedd</style></keyword><keyword><style  face="normal" font="default" size="100%">Laportea stimulans (L.f.) Gaud</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical profiles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">286-295</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Laportea decumana&lt;/em&gt; (Roxb.) Wedd. and &lt;em&gt;Laportea&lt;/em&gt; stimulans (L.f.) Miq. (Urticaceae) or itchy leaves are endogenous plants from The Maluku Islands, Indonesia, which are used topically as analgesics by local people.&lt;strong&gt; Objective&lt;/strong&gt;: As part of a preliminary investigation on the itchy leaves, this study was conducted to provide information on their macroscopic and microscopic characteristics, phytochemical profiles, and bioactivities according to the ethnomedicinal usages. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The macroscopic examination was carried out on fresh leaves. The microscopic examination was carried out on leaf powder under a light microscope. The phytochemical analyses using TLC were conducted on those crude extracts and fractions. The bioactivity assays were conducted&lt;em&gt; in vitro&lt;/em&gt; as Cox-2 inhibitory and DPPH radical scavenging activities. Results: reveal similar characteristics in the macroscopic and microscopic properties of both &lt;em&gt;Laportea &lt;/em&gt;spp. leaves. Calcium oxalate crystals were observed in&lt;em&gt; L. decumana&lt;/em&gt; but not found in &lt;em&gt;L. stimulans.&lt;/em&gt; Both species have stomata with anisocytic type. More trichomes are found in the leaves of&lt;em&gt; L. decumana,&lt;/em&gt; yet smaller and easily detachable. TLC analyses exhibited slightly different profiles. The crude extracts and fractions at 10 μg/ml showed similar inhibitory percentages on Cox-2. The DPPH scavenging activities of the crude extracts and fractions of&lt;em&gt; L. decumana &lt;/em&gt;showed active moderate activity with an IC50 value &amp;lt; 250 μg/ml, while those of &lt;em&gt;L. stimulans&lt;/em&gt; showed moderate to weak potency with an IC50 value &amp;lt; 500 μg/ml. &lt;strong&gt;Conclusion: &lt;/strong&gt;Further exploration on Laportea spp. pharmacological activity is recommended to provide stronger evidence for its ethnomedicinal usage.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">06</style></accession-num><section><style face="normal" font="default" size="100%">286</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lukman La Basy&lt;sup&gt;1,2&lt;/sup&gt;, Djoko Santosa&lt;sup&gt;3&lt;/sup&gt;, Retno Murwanti&lt;sup&gt;4&lt;/sup&gt;, Triana Hertiani&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmaceutical Sciences Doctoral Study Program, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacy Department, Stikes Maluku Husada, Maluku 97566, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, INDONESIA.&lt;/p&gt;
</style></auth-address></record></records></xml>