<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Omar Khaled Al-Mobideen</style></author><author><style face="normal" font="default" size="100%">Ali Abdallah Alqudah</style></author><author><style face="normal" font="default" size="100%">Ahmed Al-Mustafa</style></author><author><style face="normal" font="default" size="100%">Fuad Alhawarat</style></author><author><style face="normal" font="default" size="100%">Hussam Mizher</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Crataegus aronia on the Biochemical Parameters in Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Biochemical parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Crataegus aronia</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">587-595</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Crataegus aronia&lt;/em&gt; is widely known for its antioxidant, anti-inflammatory, and hypolipidemic properties, and it has traditionally been used to treat cardiovascular disorders. This study aimed to evaluate the impact of &lt;em&gt;Crataegus aronia&lt;/em&gt; extract on the liver enzyme markers, blood glucose levels, lipid profiles, and kidney function biomarkers as well as hematological parameters in induced diabetic rats. Male Wistar rats were divided into seven groups: normal Control; Diabetic; and Diabetic animals treated with two doses of &lt;em&gt;Crataegus aronia&lt;/em&gt; extract (5 and 10mg/kg) (DM + extract), Control treated with the extract ( 5 and 10mg/ kg) and induced diabetic treated with insulin. Streptozotocin (STZ)-induced diabetic rats (50 mg/kg, ip)and normal were orally administrated with &lt;em&gt;Crataegus aronia&lt;/em&gt; extract once a day for 4 weeks. At the end of the experiment, the biochemical and hematological parameters were measured in all groups. Also, the phytochemicals and antioxidant activity of the &lt;em&gt;Crataegus aronia&lt;/em&gt; extract were evaluated. According to findings, the total phenols, total flavonoid, and flavonol contents were 538.3 mg Galic acid equivalent /g extract, 149.3 mg Rutin equivalent / g extract, and 79.3 mg Rutin equivalent / g extract), respectively. The antioxidant activity according to 2,2-diphenyl-2-picrylhydrazyl (DPPH) IC&lt;sub&gt;50&lt;/sub&gt; and ferric reducing antioxidant power (FRAP) assays were 28.02 μg/ml and in the range of 0.273 – 0.960 μmol Fe&lt;sup&gt;+2&lt;/sup&gt;/g dw, respectively. &lt;em&gt;Crataegus aronia &lt;/em&gt;extract significantly (p &amp;lt;0.05) affects red blood cells, hemoglobin, hematocrit, white blood cells, lymphocytes, and platelets values. Also, &lt;em&gt;Crataegus aronia&lt;/em&gt; had a significant (P &amp;lt; 0.05) effect on serum biochemical parameters, including glucose, total proteins, albumins, triglycerides, creatinine, bilirubin, and serum aspartate aminotransferase (AST). However, &lt;em&gt;Crataegus aronia&lt;/em&gt; treatment had no significant effects (p &amp;lt; 0.05) on serum alanine aminotransferase, alkaline phosphatase, and cholesterol levels.&lt;em&gt; Crataegus aronia &lt;/em&gt;exerts antioxidant activity and significantly improves the biochemical and hematological biomarkers in induced diabetic rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">587</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Omar Khaled Al-Mobideen&lt;sup&gt;1&lt;/sup&gt;, Ali Abdallah Alqudah&lt;sup&gt;2&lt;/sup&gt;, Ahmed Al- Mustafa&lt;sup&gt;3*&lt;/sup&gt;,Fuad Alhawarat&lt;sup&gt;1&lt;/sup&gt;, Hussam Mizher&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of paramedics, Prince Al-Hussein bin Abdullah II Academy of Civil Protection, Al- Balqa' Applied University, JORDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Applied Biology, Tafila Technical University, JORDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Mutah University, JORDAN. 4Department of Basic Medical Sciences, Kulliyyah of Pharmacy, Pahang, MALAYSIA.&lt;/p&gt;
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