<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Funsho Oyetunde-Joshua</style></author><author><style face="normal" font="default" size="100%">Roshila Moodley</style></author><author><style face="normal" font="default" size="100%">Hafizah Cheniah</style></author><author><style face="normal" font="default" size="100%">Rene Khan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical and Biological Studies of Helichrysum acutatum DC</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Caffeic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Magnetic resonance</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">603-609</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Helichrysum acutatum &lt;/em&gt;from the Asteraceae family is a shrub indigenous to Southern Africa. The plant is used in traditional medicine as an enema for newborn babies. This study aimed to isolate and identify the bioactive constituents from &lt;em&gt;H. acutatum.&lt;/em&gt; In addition, the crude extracts and isolated compounds were tested for their antioxidant, antibacterial and cytotoxic activities. The phytochemical investigation afforded the known compounds stigmasterol, stigmasterol glucoside, and caffeic acid. The antioxidant activity of the ethyl acetate extract showed higher activity compared to other extracts, ascorbic acid and butylated hydroxytoluene. Antibacterial profiling of all the extracts showed no activity against Gram-negative and Gram-positive bacterial strains. The cytotoxic activity of the crude extracts was assayed&lt;em&gt; in vitro&lt;/em&gt; against two human cancer cell lines, liver hepatoblastoma (HepG2) and colorectal adenocarcinoma (Caco-2). The human embryonic kidney cell line (Hek-293) was used as the non-transformed control. The plant extracts showed insufficient antiproliferative or cytotoxic activity to the tumour and regular cell lines tested, which signifies suitable for human consumption. Overall, this plant has better antioxidant activity than other plants in the genus, which needs further exploration.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">603</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Funsho Oyetunde-Joshua&lt;sup&gt;1&lt;/sup&gt;, Roshila Moodley&lt;sup&gt;1,*&lt;/sup&gt;, Hafizah Cheniah&lt;sup&gt;2&lt;/sup&gt;, Rene Khan&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Private Bag X 54001, Durban, 4000, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Life Sciences, University of KwaZulu- Natal, Westville Campus, Private Bag X54001, Durban 4000, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Howard College Campus, Durban 4041, SOUTH AFRICA.&lt;/p&gt;
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