<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bhuvaneshwari. J</style></author><author><style face="normal" font="default" size="100%">Thirumalai Vasan. P</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bio-Evaluation, In-Vitro and In-Vivo Anti-Inflammatory Activity, Therapeutic Efficacy, and Genotoxicity of the Potentials of the Green Seaweed Valoniopsis Pachynema using Zebra Fish Larvae (Danio Rerio) as an Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactive compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Marine algae</style></keyword><keyword><style  face="normal" font="default" size="100%">V. pachynema</style></keyword><keyword><style  face="normal" font="default" size="100%">Zebra fish larvae drug toxicity.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">1037-1053</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Advancement in the medical sectors to treat regular diseases are increasing day-by-day. Yet, there is a considerable growth in the demand for the natural/herbal products as well due to their low level of side effects, cost efficiency and their multiple inhibition properties. Based on this, the present research works with an objective to examine the bioactive components, &lt;em&gt;in vitro&lt;/em&gt; anti-inflammatory and in vivo antiinflammatory behaviour of the green marine macro algae &lt;em&gt;Valoniopsis pachynema &lt;/em&gt;using zebra fish (Danio rerio) larvae as a skin inflammation model. In this study, the secondary metabolites are extracted using methanol solvent from the marine green seaweed, &lt;em&gt;V. pachynema&lt;/em&gt; using the Gas Chromatography-Mass Spectrometry (GC-MS) analysis and these are further evaluated for their anti-inflammatory effects. Further screening process is accomplished for the&lt;em&gt; in vitro &lt;/em&gt;anti-inflammatory activity by the albumin-denaturation inhibition. Results from concentration-dependent analysis is documented. The efficacy, therapeutic efficacy, and genotoxicity of the compound Valp at various concentrations are determined by recapitulating the pathophysiology of Skin inflammation in Zebrafish larvae. In evaluating the efficiency of the study, Valp at 1 pg, 10 pg, 100 pg are observed and progressed for the evaluation of therapeutic efficacy and genotoxicity. In the assessment of genotoxicity, the gene expression of mgmt gene is observed to be in control level at Valp 100 pg treated group confirming no genotoxicity. According to the results obtained, the green seaweed&lt;em&gt; V. pachynema&lt;/em&gt; can be potentially explored as an effectual anti-inflammatory agent for its bio-functionalities&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">1037</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bhuvaneshwari. J&lt;sup&gt;1&lt;/sup&gt;, Thirumalai Vasan. P&lt;sup&gt;2,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar and adjunct faculty, Department of Biotechnology, Srimad Andavan College of Arts and Science (Autonomous), Affiliated to Bharathidasan University, Thiruvanaikovil, Tiruchirapalli, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor and Head, Department of Biotechnology, Srimad Andavan College of Arts and Science (Autonomous), Affiliated to Bharathidasan University, Thiruvanaikovil, Tiruchirapalli, Tamil Nadu, INDIA&lt;/p&gt;
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