<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rajeshwari Shastry</style></author><author><style face="normal" font="default" size="100%">Aadhya Sharma</style></author><author><style face="normal" font="default" size="100%">Vinay Sayeli</style></author><author><style face="normal" font="default" size="100%">Ullal Sheetal Dinkar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Screening of Antidepressant Activity of Punica granatum in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Forced swim test</style></keyword><keyword><style  face="normal" font="default" size="100%">Pomegranate.</style></keyword><keyword><style  face="normal" font="default" size="100%">Tail suspension test</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">27-29</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; India is a rich source of medicinal plants used therapeutically to treat various disorders including depression. This study was undertaken to evaluate the antidepressant effect of acute and chronic administration of &lt;em&gt;Punica granatum&lt;/em&gt; (pomegranate) whole fruit in mice. &lt;strong&gt;Methods:&lt;/strong&gt; We used the aqueous extract of &lt;em&gt;Punica granatum &lt;/em&gt;(250 and 500 mg/kg per day), standard drug used was Imipramine (10 mg/kg) and vehicle was gum acacia (10 ml/kg), orally. Four groups of animals were used and each group had six animals. In the acute study drugs/vehicles were administered 60 min prior to the experiments. In the chronic study drugs/vehicles were administered for 14 days and the last dose was given on the 14&lt;sup&gt;th&lt;/sup&gt; day, 60 minutes prior to experiment. Forced Swim Test and Tail Suspension Test were used for testing antidepressant activity. Data was analyzed using one-way ANOVA with drug treatment as the independent factor. Post-hoc comparisons were performed using Dunnett&amp;rsquo;s test. &lt;strong&gt;Results: &lt;/strong&gt;In acute and chronic forced swim test as well as acute tail suspension test, duration of immobility was significantly reduced in the PG 500 mg/kg, but not in the 250 mg/kg treated group. In chronic tail suspension test, duration of immobility was significantly decreased in PG 250 mg/kg and 500 mg/kg treated groups. The antidepressant activity of 500 mg/kg was comparable to that of Imipramine 10 mg/kg. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study suggests that aqueous extract of whole fruit of P. granatum has antidepressant activity at 500 mg/kg. It would be advisable to encourage consumption of pomegranate extract in patients with depression because of its nutritional and functional properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">27</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Rajeshwari Shastry, Aadhya Sharma, Vinay Sayeli, Ullal Sheetal Dinkar* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology, Kasturba Medical College, Mangaluru,Manipal University, Karnataka, INDIA.&lt;/p&gt;
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